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Glossary In Vitro Models

experimental systems studying biological processes outside living organisms

In Vitro Models refer to experimental systems used to study biological processes outside of a living organism, typically in a controlled laboratory environment. These models often involve the use of cell cultures or tissue samples to investigate cellular behaviors, drug responses, or disease mechanisms, providing valuable insights without the ethical and practical complexities of in vivo (within a living organism) studies.

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Research

5 / 1000+ results

research Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin

8 citations , December 2024 in “Frontiers in Medicine”

In this study, different treatments on ex vivo skin models effectively simulated varying levels of skin damage, demonstrating the value of these models in testing skin repair products and studying how a compromised skin barrier affects viral penetration.

Evaluation of Hair Growth-Promoting, Anti-Inflammatory, and 5α-Reductase Inhibitory Effects of Spirulina Extract Using In Vitro and In Vivo Models

research Evaluation of hair growth-promoting, anti-inflammatory, and 5α-reductase inhibitory effects of Spirulina extract using in vitro and in vivo models

July 2025 in “Biotechnology and Bioprocess Engineering”

Spirulina extract may effectively promote hair growth and reduce inflammation, offering a natural alternative for hair loss treatment.

research Assessing the effect of cleansing products on artificially polluted human hairs and skin through in vivo and in vitro models

January 2023 in “Skin Research and Technology”

This study created new methods to test how well hair care products clean and protect hair from pollution, finding a wide range of effectiveness among different formulas in removing pollutants and preventing their deposit on hair fibers.

research Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

208 citations , January 2013 in “Lab on a Chip”

The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.

research PLACENTA EXTRACT-LOADED NOVASOME SIGNIFICANTLY IMPROVED HAIR GROWTH IN A RAT IN VIVO MODEL

1 citations , May 2023 in “International Journal of Applied Pharmaceutics”

In this study, the researchers developed a novasome vesicle carrying bovine placenta extract, which demonstrated superior hair growth effects in rats compared to traditional minoxidil and PE-loaded liposomes, and showed good stability and physical characteristics over 90 days at 4°C.

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Community Join

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community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

13 upvotes 3 years ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

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Learn

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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Clinics

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