TLDR Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.
The document "Cell Therapy for Androgenetic Alopecia: Elixir or Trick?" discusses the potential of stem cell therapies for treating Androgenetic Alopecia (AGA), a common form of hair loss affecting approximately 50% of men and 45% of women by the age of 50. Current treatments, including drugs, hair transplantation, and low laser therapy, have limitations and side effects. Stem cell-based therapies, which reactivate hair follicle stem cells to promote growth and regeneration, are gaining attention. Examples of successful stem cell treatments include adipose-derived stem cell component extract (ADSC-CE) for AGA, and the transplantation of human hair follicle mesenchymal stem cells (hHF-MSCs) into the scalp of 27 patients, resulting in increased hair density. However, these therapies face regulatory and safety challenges, including the risk of tumorigenesis and infection transmission. The document concludes that while stem cell therapies offer a promising alternative treatment for hair loss, further research, including double-blind controlled clinical trials, is needed to fully understand their therapeutic potential and safety.View this study on link.springer.com →
Androgenetic alopecia, a genetic disorder affecting up to 50% of adults, is caused by an excessive response to androgens leading to hair follicle shrinkage. Treatments include FDA-approved drugs, other therapies like low-dose oral minoxidil, and hair transplantation.
Hair loss in both Androgenetic Alopecia and Alopecia Areata is often accompanied by inflammation around hair follicles, but the location and severity of this inflammation varies.
Fat injections can help regrow hair in stubborn hair loss cases.
Light therapy reduces scalp inflammation, boosts hair regrowth with Minoxidil 2%.
Deeper microneedling boosts hair growth, with 0.6mm needles and minoxidil being most effective.
Smoking increases early hair loss risk in men; quitting may help prevent it.
Impaired autophagy may cause hair loss by triggering early catagen.
DHT stops hair regrowth in mice, similar to human hair loss.
Adding insulin-like growth factor 1 and bone marrow-derived stem cells to a collagen-chitosan scaffold helps wounds heal faster and regrows hair follicles.
ADSC-CE treatment safely increases hair density and thickness in androgenetic alopecia patients.
Platelet-Rich Plasma (PRP) can promote new hair growth and increase hair density, but its effectiveness varies depending on the type of hair loss.
A substance from a specific gel helped to grow hair effectively in mice, suggesting it could potentially be used to treat hair loss in humans.
Micrografts promote hair growth in androgenetic alopecia treatment.
PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.
Hair growth medium helps heal wounds and regrow hair in mice.
Injected cells show potential for hair growth.
Poor sleep, meat-heavy diets, and junk food worsen hair loss, while sugary drinks may help.
Combining electrodynamic microneedle with 5% minoxidil improves hair growth and reduces hair loss in Chinese men.
Hair loss in men is mainly caused by hormones and genes, and while current treatments can slow it down, they can't fully stop it.
Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.
Finasteride boosts stem cell signals for hair growth.
Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
Platelet-Rich Plasma and stem cell therapy can increase hair count and density, but the best method for preparation and treatment still needs to be determined.
Hair loss patients have different microbes in hair follicles, possibly affecting hair loss.
PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.
Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.
Combined microneedling and minoxidil improves hair growth more than minoxidil alone.
Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.
Hair loss drugs may cause sexual issues and infertility in men.
The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.
AGA linked to inflammation, stress, fibrosis, and disturbed hair follicle stem cells.
Stem cells from hair follicles can safely treat hair loss.
Hair loss in women links to inflammation around hair follicles.
New genes found linked to balding, may help develop future treatments.
Stem cell therapy could be a promising alternative for hair regrowth with fewer side effects.
New model shows muscle affects hair loss differently in men and women.
ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.
Oxidative stress affects hair loss in men with androgenetic alopecia.
Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.
Crescina® lotion helps reduce hair loss and increase hair growth in males with androgenetic alopecia.
Asian hair loss differs from Europeans; consider individual needs and psychological well-being for treatment.
AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.
No link found between specific genes and female pattern hair loss.
Male pattern baldness involves hormones and cell signals affecting hair growth.
New genetic insights have improved understanding of hair loss, leading to a new test and treatments, but more research is needed on the test and laser comb effectiveness.
Alopecia common in teens, may indicate endocrine issue, minoxidil effective treatment.
Aromatase gene variation may increase female hair loss risk.
Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.
Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.
Stem cell therapies show promise for treating hair loss, but more research is needed to understand their safety and effectiveness.
Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.