Therapeutic Effects of Stem Cells in Different Body Systems: A Comprehensive Review

July 2021 in “ Bosnian Journal of Basic Medical Sciences ”

Alireza Ebrahimi, Hanie Ahmadi, Zahra Pourfraidon Ghasrodashti, Nader Tanide, Reza Shahriarirad, Amirhossein Erfani, Keivan Ranjbar, Soheil Ashkani‐Esfahani

alopecia stem cell therapy adipose-derived stem cells follicular epithelial cells hair follicle regeneration

TLDR Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.

The document is a comprehensive review of the therapeutic effects of stem cells in different body systems, including lung, liver, kidney diseases, infertility, urinary incontinence, diabetes, leukemia, osteoarthritis, osteoporosis, hearing loss, wound healing, vitiligo, alopecia, COVID-19, and HIV. It highlights the potential of mesenchymal stem cells, spermatogonial stem cells, and allogeneic hematopoietic stem-cell transplantation in treating these conditions. For alopecia, stem cell therapy, particularly adipose-derived stem cells and follicular epithelial cells, has shown promising results in hair follicle regeneration. However, the document does not provide specific numbers of participants in the studies it cites, and it acknowledges the ethical, legal, and social issues associated with stem cell research. The document concludes that while stem cell therapy shows promise, more research is needed to fully understand their therapeutic potential and address any challenges.

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research Efficacy of Stem Cell Therapy for Burn Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies

15 citations , July 2020 in “Stem Cell Research & Therapy”

Stem cell therapy helps heal burn wounds, especially second-degree burns, by promoting blood vessel growth and reducing inflammation.

research Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

22 citations , July 2020 in “Journal of The American Academy of Dermatology”

DSC cell injections significantly improved hair density and diameter, showing potential as a hair loss treatment.

research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium

33 citations , June 2020 in “Dermatologic Surgery”

Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia in Men and Women: A Systematic Review with Network Meta-Analyses and an Assessment of Evidence Quality

15 citations , April 2020 in “Journal of Dermatological Treatment”

Minoxidil and finasteride work best for hair loss; more research needed.

research Advances in Stem Cell-Based Therapy for Hair Loss

7 citations , January 2020 in “PubMed”

Stem cell therapies show promise for treating hair loss, but more research is needed to understand their safety and effectiveness.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , February 2019 in “Skin appendage disorders”

Some alternative treatments for hair loss might work, but more research is needed.

research Therapeutic Potential of Stem Cells in Follicle Regeneration

45 citations , August 2018 in “Stem Cells International”

Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations , March 2018 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice

15 citations , July 2017 in “PubMed”

Injecting a mix of human skin and hair cells into mice can grow new hair.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , June 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

479 citations , June 2014 in “Science”

Epithelial stem cells can adapt and help in tissue repair and regeneration.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations , December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.