Therapeutic Effects of Stem Cells in Different Body Systems: A Comprehensive Review

July 2021 in “ Bosnian Journal of Basic Medical Sciences ”

Alireza Ebrahimi, Hanie Ahmadi, Zahra Pourfraidon Ghasrodashti, Nader Tanide, Reza Shahriarirad, Amirhossein Erfani, Keivan Ranjbar, Soheil Ashkani‐Esfahani

alopecia stem cell therapy adipose-derived stem cells follicular epithelial cells hair follicle regeneration

TLDR Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.

The document is a comprehensive review of the therapeutic effects of stem cells in different body systems, including lung, liver, kidney diseases, infertility, urinary incontinence, diabetes, leukemia, osteoarthritis, osteoporosis, hearing loss, wound healing, vitiligo, alopecia, COVID-19, and HIV. It highlights the potential of mesenchymal stem cells, spermatogonial stem cells, and allogeneic hematopoietic stem-cell transplantation in treating these conditions. For alopecia, stem cell therapy, particularly adipose-derived stem cells and follicular epithelial cells, has shown promising results in hair follicle regeneration. However, the document does not provide specific numbers of participants in the studies it cites, and it acknowledges the ethical, legal, and social issues associated with stem cell research. The document concludes that while stem cell therapy shows promise, more research is needed to fully understand their therapeutic potential and address any challenges.

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Research cited in this study

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research Efficacy of Stem Cell Therapy for Burn Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies

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research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia in Men and Women: A Systematic Review with Network Meta-Analyses and an Assessment of Evidence Quality

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Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

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DSC cell injections significantly improved hair density and diameter, showing potential as a hair loss treatment.

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research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium

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Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.

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Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.

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research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

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Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

19 citations, January 2017 in “Stem Cells International”

Adipose-derived stem cells show promise in treating skin conditions like vitiligo, alopecia, and nonhealing wounds.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

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Stem cell therapy may help treat tough hair loss cases.

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

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Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations, March 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

479 citations, June 2014 in “Science”

Epithelial stem cells can adapt and help in tissue repair and regeneration.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

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Hair loss increases with age; alcohol raises risk, more female partners lowers it.

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Stem cell therapy shows promise for treating hair loss in androgenetic alopecia.

research Therapeutic Potential of Stem Cells in Follicle Regeneration

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Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations, April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

13 citations, June 2020 in “Stem Cells International”

A substance from a specific gel helped to grow hair effectively in mice, suggesting it could potentially be used to treat hair loss in humans.

Therapeutic Effects of Stem Cells in Different Body Systems: A Comprehensive Review

Research cited in this study

research Efficacy of Stem Cell Therapy for Burn Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia in Men and Women: A Systematic Review with Network Meta-Analyses and an Assessment of Evidence Quality

research Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Advances in Stem Cell-Based Therapy for Hair Loss

research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

research Therapeutic Potential of Stem Cells in Follicle Regeneration

research Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

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