Guidelines for the Management of Patients with Alopecia Areata in Korea: Part I Topical and Device-Based Treatment

January 2023 in “ Annals of Dermatology ”

Hyunsun Park, Jung Eun Kim, Jee Woong Choi, Do Young ‍Kim, Yong Hyun Jang, Young Lee, Jiehyun Jeon, Hyun‐Tae Shin, Min Sung Kim, Jung Won Shin, Sung Bin Cho, Bark‐Lynn Lew, Gwang Seong Choi

alopecia areata topical treatment device-based treatment

TLDR The guidelines offer updated treatment recommendations for alopecia areata in Korea using topical and device-based methods.

The study presented evidence-based treatment guidelines for managing alopecia areata (AA) in Korea, focusing on topical and device-based treatments. It was based on a consensus among experts, taking into account regional healthcare circumstances, which added diversity to existing guidelines. The guidelines aimed to provide updated recommendations for effectively treating AA, reflecting the specific needs and conditions of patients in Korea.

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research Treatment of Pediatric Alopecia Areata: A Systematic Review

48 citations , April 2021 in “Journal of the American Academy of Dermatology”

Topical corticosteroids are the best initial treatment for children's alopecia areata.

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research Efficacy of Antihistamines in Combination with Topical Corticosteroid and Superficial Cryotherapy for Treatment of Alopecia Areata: A Retrospective Cohort Study

5 citations , July 2020 in “Journal of the American Academy of Dermatology”

Adding antihistamines to topical corticosteroid and cryotherapy may improve hair regrowth in alopecia areata patients.

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

research Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

10 citations , April 2020 in “Dermatology and therapy”

Calcipotriol works almost as well as clobetasol for mild to moderate alopecia areata with fewer side effects.

research Ophiasis Alopecia Areata Treated with Microneedling

1 citations , April 2020 in “Baylor University Medical Center Proceedings”

Microneedling with triamcinolone helps hair regrowth in ophiasis alopecia areata.

research Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis

19 citations , April 2020 in “Journal of the American Academy of Dermatology”

5 mg/mL of triamcinolone acetonide is most effective for hair regrowth with fewer side effects.

research A Comparative Study of Therapeutic Response to Intralesional Injections of Platelet-Rich Plasma Versus Triamcinolone Acetonide in Alopecia Areata

8 citations , January 2020 in “Indian Dermatology Online Journal”

PRP works faster and is a safe alternative to steroids for treating alopecia areata.

research Platelet-Rich Plasma in Alopecia Areata: Intradermal Injection Versus Topical Application with Transepidermal Delivery via Either Fractional Carbon Dioxide Laser or Microneedling

5 citations , January 2020 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

Injecting platelet-rich plasma or applying it with a laser or microneedling can treat hair loss effectively. The laser and microneedling methods cause less pain.

research Italian Guidelines in Diagnosis and Treatment of Alopecia Areata

37 citations , December 2019 in “Giornale italiano di dermatologia e venereologia”

The Italian guidelines offer advice for diagnosing and treating alopecia areata based on expert opinion and limited clinical trial evidence.

Combination of Photodynamic Therapy with 5-Aminolaevulinic Acid and Microneedling in the Treatment of Alopecia Areata Resistant to Conventional Therapies: Our Experience with 41 Patients

research Combination of Photodynamic Therapy with 5-Aminolaevulinic Acid and Microneedling in the Treatment of Alopecia Areata Resistant to Conventional Therapies: Our Experience with 41 Patients

14 citations , August 2019 in “Clinical and Experimental Dermatology”

Combining light therapy, acid, and microneedling improves hair regrowth in stubborn hair loss cases.

research The Use of a 1,540 nm Fractional Erbium-Glass Laser in the Treatment of Alopecia Areata

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The erbium-glass laser effectively promotes hair regrowth in alopecia areata.

research Topical Calcipotriol vs Narrowband Ultraviolet B in Treatment of Alopecia Areata: A Randomized-Controlled Trial

9 citations , June 2019 in “Archives of Dermatological Research”

Both topical calcipotriol and narrowband UVB improved alopecia, but combining them didn't enhance the effect on hair loss severity, despite higher vitamin D3 levels.

research Efficacy and Safety of Anthralin in Combination with Diphenylcyclopropenone in the Treatment of Alopecia Areata: A Retrospective Case Series

20 citations , June 2019 in “Archives of dermatological research”

Combining DPCP and anthralin helps regrow hair in some alopecia areata patients.

research Off-Label Use of Topical Minoxidil in Alopecia: A Review

32 citations , January 2019 in “American Journal of Clinical Dermatology”

Minoxidil helps treat eyebrow thinning, monilethrix, early hair loss, and shortens chemo-related hair loss.

research Monotherapy for Alopecia Areata: A Systematic Review and Network Meta-Analysis

16 citations , January 2019 in “Skin appendage disorders”

Intralesional corticosteroids work best for mild alopecia areata, and DPCP works best for moderate to severe cases.

research Treatment of Alopecia Areata: An Australian Expert Consensus Statement

95 citations , November 2018 in “Australasian journal of dermatology”

Alopecia areata treatment varies, with no optimal method established yet.

research Systemic Treatments for Alopecia Areata: A Systematic Review

41 citations , September 2018 in “Australasian journal of dermatology”

No systemic treatment for alopecia areata has strong evidence of effectiveness.

research Treatment of Alopecia Universalis with Topical Janus Kinase Inhibitors – A Double Blind, Placebo, and Active Controlled Pilot Study

49 citations , August 2018 in “International Journal of Dermatology”

Topical JAK inhibitors may help treat alopecia universalis by promoting hair regrowth.

research Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata

89 citations , August 2018 in “JAMA Dermatology”

Contact immunotherapy can improve hair regrowth in alopecia areata patients.

research Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata

45 citations , May 2018 in “Stem Cell Research & Therapy”

Using patients' own fat-derived cells to treat alopecia areata significantly improved hair growth and was safe.

research Topical 2% Tofacitinib for Children with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis

49 citations , May 2018 in “Journal of the American Academy of Dermatology”

Applying 2% tofacitinib cream helped some children with severe hair loss grow back hair.

research Role of Hair Prostheses (Wigs) in Patients with Severe Alopecia Areata

15 citations , January 2018 in “Annals of Dermatology”

Wigs significantly improve the well-being of people with severe hair loss.

research Efficacy of Diphenylcyclopropenone in Alopecia Areata: A Comparison of Two Treatment Regimens

10 citations , January 2018 in “Postępy Dermatologii i Alergologii”

Treating alopecia areata every 3 weeks with diphenylcyclopropenone is more effective than weekly treatments.

research An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata

12 citations , December 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

Platelet-rich plasma and microneedling could potentially help hair growth in people with alopecia areata, but more research is needed.

research Alopecia Areata: Treatment Options and Efficacy

182 citations , December 2017 in “Journal of the American Academy of Dermatology”

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

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New treatments for alopecia areata show promise, but no cure exists and responses to treatments vary.

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research Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata

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Topical DPCP is somewhat effective for hair loss in alopecia areata, but more research is needed.

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22 citations , May 2017 in “Journal of dermatological treatment”

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7 citations , January 2017 in “International Journal of Dermatology”

Superficial cryotherapy significantly improves eyebrow hair growth in alopecia universalis patients.

research Bilateral Half-Head Comparison of 1% Anthralin Ointment in Children with Alopecia Areata

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1% anthralin ointment is effective and safe for treating severe alopecia areata in children.

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PRP more effective than minoxidil 5% for treating alopecia areata.

research Efficacy and Safety of Superficial Cryotherapy for Alopecia Areata: A Retrospective Comprehensive Review of 353 Cases Over 22 Years

16 citations , October 2016 in “The Journal of Dermatology”

Superficial cryotherapy is effective and safe for treating alopecia areata, with better results when used early and frequently.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations , August 2016 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research Successful Treatment of Pediatric Alopecia Areata of the Scalp Using Topical Bimatoprost

14 citations , July 2016 in “Pediatric Dermatology”

A 9-year-old girl with alopecia areata had successful hair regrowth using bimatoprost after other treatments failed.

research 308-Nanometer Excimer Light Therapy for Alopecia Universalis Resistant to Other Treatments: A Clinical Study of 11 Patients

13 citations , April 2016 in “Journal of Dermatology”

308-nm excimer light therapy helped over a third of treatment-resistant alopecia universalis patients regrow most of their hair.

research An Evaluation of the Safety and Efficacy of Bimatoprost for Eyelash Growth in Pediatric Subjects

16 citations , March 2016 in “Clinical ophthalmology”

Bimatoprost is safe and improves eyelash growth in healthy kids but not in those with eyelash loss from chemotherapy or alopecia.

research Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis

128 citations , February 2016 in “British Journal of Dermatology”

Alopecia areata significantly lowers the quality of life, especially in emotional and mental health aspects.

research Retrospective Review of Diphencyprone in the Treatment of Alopecia Areata

27 citations , December 2015 in “Clinical and Experimental Dermatology”

Diphencyprone helped most patients with alopecia areata regrow some hair.

research Intralesional Triamcinolone Acetonide Versus Topical Betamethasone Valerate in the Management of Localized Alopecia Areata

18 citations , December 2015 in “PubMed”

Intralesional triamcinolone is more effective than topical betamethasone for treating localized alopecia areata.

research Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients

41 citations , November 2015 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Diphenylcyclopropenone (DPCP) can help regrow hair in many alopecia areata patients but may cause side effects and relapses.

research Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study

38 citations , June 2015 in “PubMed”

Calcipotriol cream can effectively and safely treat mild-to-moderate patchy hair loss.

research Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy

55 citations , April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

44 citations , February 2015 in “Journal of the American Academy of Dermatology”

Combining diphenylcyclopropenone with anthralin is more effective for hair regrowth in alopecia areata than using diphenylcyclopropenone alone, but may cause more side effects.

research Comparative Evaluation of Intralesional Triamcinolone Acetonide Injection, Narrow Band Ultraviolet B, and Their Combination in Alopecia Areata

18 citations , January 2015 in “International Journal of Trichology”

Intralesional steroids are more effective for hair regrowth in alopecia areata than NBUVB, but combining them doesn't improve results.

research Effectiveness of 308-nm Excimer Laser Therapy in Treating Alopecia Areata by Examining Treated Sides of Selected Alopecic Patches

30 citations , January 2015 in “Dermatology”

308-nm excimer laser therapy helps regrow hair in alopecia areata.

research Minoxidil-Induced Hypertrichosis in Children

12 citations , January 2014 in “The Pan African medical journal”

Minoxidil caused unwanted hair growth in a child, but stopped after stopping treatment.

research Alopecia Areata: Successful Outcome with Microneedling and Triamcinolone Acetonide

53 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

Microneedling combined with triamcinolone can safely stimulate faster hair regrowth in people with Alopecia Areata.

research Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children

49 citations , November 2013 in “JAMA dermatology”

Clobetasol propionate, 0.05%, is more effective and safe for treating childhood alopecia areata than hydrocortisone, 1%.

research Minoxidil Induced Hypertrichosis in a 2-Year-Old Child

17 citations , October 2013 in “F1000Research”

A 2-year-old boy grew excessive hair after using minoxidil for hair loss, but it improved when the treatment stopped.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research The Safety and Efficacy of Diphencyprone for the Treatment of Alopecia Areata in Children

37 citations , September 2012 in “Archives of dermatology”

Diphencyprone can help some children with alopecia areata regrow hair, but it often causes side effects.

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

218 citations , April 2012 in “British Journal of Dermatology”

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

research Narrowband Ultraviolet B Phototherapy for Alopecia Areata

37 citations , November 2011 in “Photodermatology Photoimmunology & Photomedicine”

Narrowband UVB phototherapy alone is not very effective for treating alopecia areata.

research Comparison of Treatment with Clobetasol Propionate 0.05% and Topical Pimecrolimus 1% in Alopecia Areata

13 citations , July 2011 in “Journal of Dermatological Treatment”

Clobetasol and pimecrolimus are similarly effective for alopecia areata, but pimecrolimus has fewer side effects and is preferred for long-term use.

Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata

research Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata

48 citations , January 2011 in “International journal of trichology”

Intralesional triamcinolone acetonide is the most effective treatment for localized alopecia areata.

Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

research Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

13 citations , June 2010 in “Journal of dermatological treatment”

Diphencyprone is effective for treating patchy hair loss in alopecia areata, but tacrolimus is not.

Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

research Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

27 citations , May 2010 in “Dermatologic surgery”

Photodynamic therapy with methyl 5-aminolevulinic acid is ineffective for treating alopecia totalis.

research Bimatoprost in the Treatment of Eyelash Universalis Alopecia Areata

37 citations , January 2010 in “International Journal of Trichology”

Bimatoprost helped eyelash growth in nearly half of the patients with a type of eyelash hair loss.

research Latanoprost in the Treatment of Eyelash Alopecia in Alopecia Areata Universalis

50 citations , December 2009 in “Journal of The European Academy of Dermatology and Venereology”

Latanoprost can effectively treat eyelash hair loss, with 45% of patients showing hair regrowth and no reported side effects.

research Successful Use of Bimatoprost in the Treatment of Eyelash Alopecia

15 citations , November 2009 in “Clinical and Experimental Dermatology”

Bimatoprost helped a girl grow her eyelashes back quickly and without serious side effects.

An Unusual Anatomical Colocalization of Alopecia Areata and Vitiligo in a Child, and Improvement During Treatment with Topical Prostaglandin E2

research An Unusual Anatomical Colocalization of Alopecia Areata and Vitiligo in a Child, and Improvement During Treatment with Topical Prostaglandin E2

14 citations , November 2009 in “Clinical and experimental dermatology”

Topical prostaglandin E2 can help treat both alopecia areata and vitiligo.

research The Efficacy of Latanoprost in the Treatment of Alopecia Areata of Eyelashes and Eyebrows

20 citations , November 2009 in “European Journal of Dermatology”

Latanoprost, a glaucoma treatment, was found ineffective in treating hair loss in eyebrows and eyelashes.

research Five-Year Experience in the Treatment of Alopecia Areata with Diphencyprone

37 citations , September 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Diphencyprone (DPC) is an effective and safe long-term treatment for alopecia areata, especially with maintenance therapy.

research 308-nm Excimer Laser for the Treatment of Alopecia Areata in Children

79 citations , September 2009 in “Pediatric dermatology”

The 308-nm Excimer laser is effective and safe for treating patchy alopecia areata in children.

research Different Applications of Monochromatic Excimer Light in Skin Diseases

64 citations , June 2009 in “Photomedicine and Laser Surgery”

Excimer light effectively treats various skin diseases, including psoriasis, vitiligo, and mycosis fungoides.

Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

research Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

55 citations , March 2009 in “Journal of The American Academy of Dermatology”

Topical latanoprost and bimatoprost eye solutions don't help eyelash growth in people with alopecia areata.

research Lack of Response of Alopecia Areata to Pimecrolimus Cream

26 citations , March 2007 in “Clinical and experimental dermatology”

Pimecrolimus cream is not effective for treating alopecia areata.

research Topical Use of Minoxidil in Children and Systemic Side Effects

58 citations , January 2007 in “Dermatology”

Minoxidil use in children may cause heart issues.

research Use of the Pulsed Infrared Diode Laser (904 nm) in the Treatment of Alopecia Areata

63 citations , January 2006 in “Journal of cosmetic and laser therapy”

The pulsed infrared diode laser is effective for treating hair loss in alopecia areata.

research Lack of Efficacy of Topical Latanoprost in the Treatment of Eyebrow Alopecia Areata

36 citations , November 2005 in “Journal of The American Academy of Dermatology”

Topical latanoprost doesn't effectively regrow hair in severe eyebrow alopecia areata cases.

research Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population

36 citations , May 2005 in “BMC dermatology”

DPCP is effective for treating severe alopecia areata, but relapse is common.

research Congenital Alopecia Areata

32 citations , January 2005 in “Journal of The American Academy of Dermatology”

Some babies are born with alopecia areata, and a treatment with clobetasol propionate can regrow hair in half of the cases.

research 308-Nm Excimer Laser Therapy in Alopecia Areata

85 citations , November 2004 in “Journal of the American Academy of Dermatology”

The 308-nm excimer laser helps hair regrowth in some alopecia areata cases but not all.

research Guidelines for the Management of Alopecia Areata

182 citations , October 2003 in “British Journal of Dermatology”

The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.

research Cutaneous Latanoprost in the Treatment of Alopecia Areata

22 citations , April 2003 in “Eye”

Applying latanoprost on skin can stimulate hair growth with minimal side effects.

research The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians

275 citations , November 2002 in “International Journal of Dermatology”

Alopecia areata mainly affects young people and has significant psychological impacts, especially in males.

research Dapsone Versus Topical Immunotherapy in Alopecia Areata

13 citations , August 1995 in “British Journal of Dermatology”

Topical immunotherapy is more effective than dapsone for treating severe alopecia areata.

Treatment of Chronic Severe Alopecia Areata with Topical Diphenylcyclopropenone and 5% Minoxidil: A Clinical and Immunopathologic Evaluation

research Treatment of Chronic Severe Alopecia Areata with Topical Diphenylcyclopropenone and 5% Minoxidil: A Clinical and Immunopathologic Evaluation

41 citations , November 1993 in “Journal of The American Academy of Dermatology”

DPCP helps treat severe hair loss, but 5% minoxidil doesn't add benefits.

research Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration

33 citations , July 1992 in “Journal of Investigative Dermatology”

Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.

research Alopecia Areata in Children: Response to Treatment with Diphencyprone

84 citations , August 1991 in “British Journal of Dermatology”

Most children treated with diphencyprone regrew some or all of their hair.

research Allergic and Irritant Contact Dermatitis Compared in the Treatment of Alopecia Totalis and Universalis: A Comparison of the Value of Topical Diphencyprone and Tretinoin Gel

36 citations , March 1989 in “British journal of dermatology/British journal of dermatology, Supplement”

DPCP is more effective than tretinoin gel for treating severe alopecia.

research Treatment of Alopecia Areata With Squaric Acid Dibutylester

42 citations , August 1987 in “Archives of Dermatology”

Squaric acid dibutylester led to complete hair regrowth in 28.5% of patients with alopecia areata.

research Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy

54 citations , March 1987 in “Journal of The American Academy of Dermatology”

3% topical minoxidil effectively treats extensive alopecia areata with few side effects.

research Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata

101 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations , October 1983 in “BMJ”

Minoxidil helps hair regrowth in alopecia patients, with 16 having good results and no side effects.

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