Alopecia Areata of the Nails: Diagnosis and Management

June 2024 in “ Journal of Clinical Medicine ”

Christin Pelzer, Matilde Iorizzo

Alopecia Areata nail pitting trachyonychia leukonychia JAK inhibitors

Studysummary This study identifies various nail changes in alopecia areata, which can affect quality of life, and suggests that while spontaneous improvement is possible, further research is needed to refine treatment strategies.

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Research cited in this study

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research Clinical And Demographic Characteristics Associated With Nail Involvement In Alopecia Areata: A Cross-Sectional Study Of 197 Patients

6 citations , April 2024 in “Health Science Reports”

This study found that young patients with severe AA are more prone to nail abnormalities such as pitting and leukonychia, with koilonychia and red spots lunula in more severe cases.

research Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial

227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.

research Koilonychia in a Patient with Alopecia Areata

2 citations , February 2021 in “PubMed”

This case report describes a 25-year-old woman with alopecia areata and nail spooning, which regressed almost completely after treatment with oral corticosteroids.

Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

research Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata

56 citations , August 2020 in “American Journal of Clinical Dermatology”

This study concluded that the ClinRO and PRO measures, along with their photoguides, offer clear and meaningful assessments for patients with alopecia areata concerning eyebrow, eyelash, and nail appearance, as well as eye irritation.

research Nail Involvement in Patients with Moderate-to-Severe Alopecia Areata Treated with Oral Tofacitinib

9 citations , April 2018 in “Journal of Dermatological Treatment”

This study found that oral tofacitinib monotherapy improved nail changes in 73.3% of adults with moderate-to-severe alopecia areata over a median period of 5 months, but nail improvement was not linked to the severity of hair loss or hair regrowth.

research Nail Changes in Alopecia Areata: An Update and Review

45 citations , January 2018 in “International Journal of Dermatology”

This review explores nail changes associated with alopecia areata, noting their prevalence and impact on appearance and function, but reports no new clinical findings; the authors call for larger controlled trials.

research Alopecia Areata and Habit Tic Deformities

3 citations , January 2018 in “Skin Appendage Disorders”

This case report describes two instances of habit tic nail deformities associated with alopecia areata.

Nail Involvement in Alopecia Areata: A Questionnaire-Based Survey on Clinical Signs, Impact on Quality of Life, and Review of the Literature

research Nail Involvement in Alopecia Areata: A Questionnaire-Based Survey on Clinical Signs, Impact on Quality of Life, and Review of the Literature

19 citations , January 2018

Most people with alopecia areata have nail changes, which are common but don't greatly affect their quality of life.

research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

26 citations , October 2016 in “Case Reports in Dermatology”

In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

41 citations , December 2015 in “JAMA Dermatology”

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

research Severe Onycholysis in a Card Illusionist with Alopecia Areata Universalis

10 citations , January 2013 in “International Journal of Trichology”

This report describes a 23-year-old man with alopecia areata universalis who experienced severe nail abnormalities, which improved with systemic steroids, benefiting his work as a card illusionist.

research Clinical Characteristics and Prognostic Factors in Early-Onset Alopecia Totalis and Alopecia Universalis

38 citations , January 2012 in “Journal of Korean Medical Science”

This study found that early-onset patients with alopecia universalis or a family history of alopecia areata showed worse prognosis compared to those with late-onset.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

research The Spotted Lunula: Three Patients with Alopecia Areata Exhibited Spotty Absence of Whiteness in the Lunulae of Their Nails

30 citations , May 1980 in “Journal of the American Academy of Dermatology”

In this study, three patients with alopecia areata exhibited spotty absence of the whiteness of their nail lunulae, potentially due to defects in the matrical epithelium.