Clinical And Demographic Characteristics Associated With Nail Involvement In Alopecia Areata: A Cross-Sectional Study Of 197 Patients

April 2024 in “ Health Science Reports ”

Safoura Shakoei, Golnoosh Seifi, Farbod Ghanami, Narges Ghandi, Shahin Hamzelou, Maryam Nasimi, Ifa Etesami

alopecia areata nail abnormalities pitting distal notching linear lines koilonychia leukonychia red spots lunula

TLDR Younger patients with severe alopecia areata often have nail problems.

The study involving 197 patients with alopecia areata (AA) found that younger patients with severe forms of the disease are more likely to experience nail abnormalities. The most frequently observed nail changes were pitting, distal notching, and linear lines. Additionally, conditions such as koilonychia, leukonychia, and red spots lunula were more prevalent in cases of severe AA.

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Research cited in this study

11 / 11 results

research The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials

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The AA-IGA scale reliably measures treatment success in alopecia areata by considering both clinician and patient views.

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45 citations , January 2018 in “International Journal of Dermatology”

Nail problems are common in people with alopecia areata, often leading to cosmetic and functional issues, but more research is needed for treatment guidelines.

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research Nail Involvement in Alopecia Areata: A Questionnaire-Based Survey on Clinical Signs, Impact on Quality of Life, and Review of the Literature

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research Epidemiology and Burden of Alopecia Areata: A Systematic Review

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Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Clinical Characteristics and Prognostic Factors in Early-Onset Alopecia Totalis and Alopecia Universalis

38 citations , January 2012 in “Journal of Korean Medical Science”

Early-onset alopecia, especially with a family history, leads to worse outcomes and more related health issues.

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391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

44 citations , December 2005 in “Journal of Investigative Dermatology”

Certain genetic markers, especially the MICA gene, are linked to alopecia areata.

research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata is an autoimmune disease causing hair loss, treatable with immune-modulating drugs, and linked to genetics.

research The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians

275 citations , November 2002 in “International Journal of Dermatology”

Alopecia areata mainly affects young people and has significant psychological impacts, especially in males.

research The Spotted Lunula: Three Patients with Alopecia Areata Exhibited Spotty Absence of Whiteness in the Lunulae of Their Nails

30 citations , May 1980 in “Journal of the American Academy of Dermatology”

Alopecia areata can cause spotty white areas on nails.

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Clinical And Demographic Characteristics Associated With Nail Involvement In Alopecia Areata: A Cross-Sectional Study Of 197 Patients

Research cited in this study

research The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials

research Nail Changes in Alopecia Areata: An Update and Review

research Nail Involvement in Alopecia Areata: A Questionnaire-Based Survey on Clinical Signs, Impact on Quality of Life, and Review of the Literature

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

research Clinical Characteristics and Prognostic Factors in Early-Onset Alopecia Totalis and Alopecia Universalis

research Alopecia Areata Update

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

research Autoimmunity: Alopecia Areata

research The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians

research The Spotted Lunula: Three Patients with Alopecia Areata Exhibited Spotty Absence of Whiteness in the Lunulae of Their Nails

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