Efficacy of Superficial Cryotherapy on the Eyebrows of Patients With Alopecia Universalis Also Treated With Contact Immunotherapy on the Scalp: A Prospective, Split-Face Comparative Study

This study evaluated the efficacy of superficial cryotherapy on the eyebrows of 20 patients with alopecia universalis who were also treated with diphenylcyclopropenone (DPCP) immunotherapy on the scalp. Superficial cryotherapy was applied every other week to the right eyebrow, while the left eyebrow served as a control. After 5 months, hair density increased significantly in both treated and control eyebrows, with a greater increase in the SC-treated eyebrows. Hair thickness also significantly increased in the SC-treated eyebrows but not in the control eyebrows. The treatment was associated with minimal to no adverse events, high compliance, and relatively good efficacy, making it a viable option for patients with AA of the eyebrow.