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In this retrospective study, 60.9% of patients with alopecia areata responded to superficial hypothermic cryotherapy, with effectiveness notably higher when the treatment interval was 2 weeks or less, particularly in early disease stages, and minimal side effects were observed.

This study found that superficial cryotherapy significantly increased hair density and thickness in treated eyebrows compared to untreated controls after 5 months in patients with alopecia areata.

This study suggests that using antihistamines alongside a regimen of topical corticosteroid and superficial cryotherapy may enhance hair regrowth in patients with mild to moderate alopecia areata.

This study found that both superficial cryotherapy and intralesional corticosteroid injections significantly improved hair growth in patients with alopecia areata, with similar efficacy between the two treatments, establishing cryotherapy as a simple and noninvasive treatment option.

This article reviews the potential and limitations of cryotherapy for alopecia areata in middle-aged patients and highlights the need for further research, without reporting new clinical findings.