Image

    Therapeutic Potential of Stem Cells in Follicle Regeneration

    August 2018 in “ Stem Cells International ”
    Agnieszka Owczarczyk-Saczonek, Magdalena Krajewska-Włodarczyk, Anna Kruszewska … Joanna Wojtkiewicz
    Studysummary This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on downloads.hindawi.com →
    Discuss this study in the Community →

    Research cited in this study 73

    1. Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata Stem Cell Research & Therapy · 2018
    2. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    3. NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    4. Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice PubMed · 2017
    5. Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness Stem cells and cloning · 2017
    6. Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss Current stem cell research & therapy · 2017
    7. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    8. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    9. Human Mesenchymal Stem Cell-Derived Conditioned Media for Hair Regeneration Applications PubMed · 2017
    10. Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss Nature Cell Biology · 2017
    11. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    12. Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration Histochemistry and Cell Biology · 2017
    13. Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging International Journal of Molecular Sciences · 2017
    14. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    15. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice Stem Cells International · 2017
    16. Enhanced Expansion and Sustained Inductive Function of Skin-Derived Precursor Cells in Computer-Controlled Stirred Suspension Bioreactors Stem cells translational medicine · 2016
    17. Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia Journal of Dermatological Treatment · 2016
    18. Familial Frontal Fibrosing Alopecia Treated With Dutasteride, Minoxidil, and Artificial Hair Transplantation Australasian Journal of Dermatology · 2016
    19. Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction Scientific Reports · 2016
    20. Neural Stem Cells Restore Hair Growth Through Activation of the Hair Follicle Niche Cell Transplantation · 2016
    21. LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway Stem cell research & therapy · 2016
    22. Poor Capability of 3D-Cultured Adipose-Derived Stem Cells to Induce Hair Follicles in Contrast to 3D-Cultured Dermal Papilla Cells Annals of Dermatology · 2016
    23. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    24. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    25. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    26. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    27. Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration World Journal of Stem Cells · 2015
    28. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    29. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    30. Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration Experimental Dermatology · 2014
    31. Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth PloS one · 2014
    32. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    33. Adipose Derived Stem Cells and Growth Factors Applied in Hair Transplantation: Follow-Up of Clinical Outcome Journal of Cosmetics, Dermatological Sciences and Applications · 2014
    34. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    35. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    36. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    37. An Analysis of Follicular Punches, Mechanics, and Dynamics in Follicular Unit Extraction Facial Plastic Surgery Clinics of North America · 2013
    38. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    39. Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells Journal of Investigative Dermatology · 2013
    40. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    41. HMSCs Possess the Potential to Differentiate Into DP Cells In Vivo and In Vitro Cell Biology International Reports · 2012
    42. Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation Scientific Reports · 2012
    43. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    44. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    45. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    46. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    47. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    48. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    49. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    50. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    51. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    52. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011
    53. Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication Journal of dermatological science · 2010
    54. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    55. Optimization of the Reconstruction of Dermal Papilla-Like Tissues Employing Umbilical Cord Mesenchymal Stem Cells Biotechnology and bioprocess engineering · 2010
    56. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    57. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    58. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    59. Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine Biochemical Engineering Journal · 2009
    60. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    61. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    62. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    63. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    64. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    65. Ber-EP4 Antigen Is a Marker for a Cell Population Related to the Secondary Hair Germ Experimental Dermatology · 2004
    66. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003
    67. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    68. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    69. Modeling the Dynamics of Human Hair Cycles by a Follicular Automaton Proceedings of the National Academy of Sciences · 2000
    70. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    71. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998
    72. Proliferation and Differentiation of Organoid Hair Follicle Cells Co-Cultured with Fat Cells in Collagen Gel Matrix Culture British Journal of Dermatology · 1998
    73. Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice The EMBO Journal · 1993

    Related research 2

    1. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    2. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008