HMSCs Possess the Potential to Differentiate Into DP Cells In Vivo and In Vitro

The study demonstrated that human mesenchymal stem cells (hMSCs) had the potential to differentiate into dermal papilla (DP) cells, which are essential for hair follicle development and hair growth, both in vitro and in vivo. In vitro, hMSCs co-cultured with DP cells showed increased expression of cytokines such as SCF, ET-1, and bFGF, as well as elevated expression of CD133 and versican, leading to increased cell aggregation. In vivo experiments in mice confirmed that hMSCs could differentiate into DP cells, as evidenced by the expression of HLA-I in newly formed hair follicles. These findings suggested that hMSCs could be a promising source for generating DP cells, offering potential for hair regeneration therapies.