Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study

    January 2022 in “ Aesthetic surgery journal ”
    Gordon H. Sasaki
    Studysummary In this study, intradermal injections of extracellular vesicles over six months were reported to be safe and effective in improving hair growth among patients with pattern hair loss, with favorable response linked to specific patient factors and treatment volumes.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on academic.oup.com →
    Discuss this study in the Community →

    Research cited in this study 57

    1. The Effects of Lower vs Higher Cell Number of Platelet-Rich Plasma on Hair Density and Diameter in Androgenetic Alopecia: A Randomized, Double-Blinded, Placebo, Parallel-Group Half-Scalp IRB-Approved Study Aesthetic Surgery Journal · 2021
    2. Platelet-Rich Plasma and Cell Therapy Dermatologic clinics · 2021
    3. Female Pattern Hair Loss: Why the Follicular Unit Transplantation Surgical Technique Remains a Good Option Plastic and Reconstructive Surgery · 2021
    4. Platelet-Rich Plasma for Androgenetic Alopecia: Efficacy Differences Between Men and Women Dermatologic Therapy · 2020
    5. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    6. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    7. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia in Men and Women: A Systematic Review with Network Meta-Analyses and an Assessment of Evidence Quality Journal of Dermatological Treatment · 2020
    8. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    9. Cell-Enriched Autologous Fat Grafts to Follicular Niche Improves Hair Regrowth in Early Androgenetic Alopecia Aesthetic Surgery Journal · 2020
    10. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    11. Exosomes: A New Effective Non-Surgical Therapy for Androgenetic Alopecia? Skinmed · 2020
    12. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium Dermatologic Surgery · 2019
    13. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    14. Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons Aesthetic Plastic Surgery · 2018
    15. Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels Journal of The American Academy of Dermatology · 2018
    16. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    17. Introducing Platelet-Rich Stroma: Platelet-Rich Plasma and Stromal Vascular Fraction Combined for the Treatment of Androgenetic Alopecia Aesthetic Surgery Journal · 2018
    18. A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media Promotes Tissue Regeneration Stem Cells International · 2018
    19. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    20. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017
    21. Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness Stem cells and cloning · 2017
    22. Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss Current stem cell research & therapy · 2017
    23. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    24. Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells Current stem cell research & therapy · 2017
    25. Genetics and Other Factors in the Etiology of Female Pattern Hair Loss Experimental Dermatology · 2017
    26. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    27. Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia Journal of Dermatological Treatment · 2016
    28. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia Dermatologic Surgery · 2016
    29. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    30. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    31. Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration World Journal of Stem Cells · 2015
    32. Eyebrow Regrowth in Patient with Atrophic Scarring Alopecia Treated with an Autologous Fat Graft PubMed · 2014
    33. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    34. Prospect of Stem Cell Conditioned Medium in Regenerative Medicine BioMed Research International · 2014
    35. The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation BioMed Research International · 2014
    36. Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Journal of Investigative Dermatology · 2013
    37. Hair Transplantation Update Dermatologic Clinics · 2012
    38. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    39. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    40. Alopecia: Evaluation and Treatment Clinical, Cosmetic and Investigational Dermatology · 2011
    41. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    42. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    43. Successful Treatment of Temporal Triangular Alopecia by Hair Restoration Surgery Using Follicular Unit Transplantation Dermatologic Surgery · 2009
    44. The Effects of Autologous Platelet-Rich Plasma and Various Growth Factors on Non-Transplanted Miniaturized Hair Hair transplant forum international · 2009
    45. Understanding and Management of Female Pattern Alopecia Facial Plastic Surgery · 2008
    46. Female Pattern Hair Loss Springer eBooks · 2008
    47. The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery Plastic and reconstructive surgery/PSEF CD journals · 2006
    48. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    49. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    50. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    51. Is Androgenic Alopecia a Result of Endocrine Effects on the Vasculature? Medical Hypotheses · 2003
    52. Follicular Unit Extraction: Minimally Invasive Surgery for Hair Transplantation Dermatologic Surgery · 2002
    53. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    54. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    55. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    56. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993
    57. The Psychological Effects of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 1992

    Related research 2

    1. Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study Aesthetic surgery journal · 2022
    2. The Clinical Efficacy and Safety of Autologous Activated Platelet-Rich Plasma Injection in Androgenetic Alopecia Skin appendage disorders · 2019