A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media Promotes Tissue Regeneration

In the 2018 study, researchers found that conditioned media from deer antlerogenic mesenchymal stem cells (DaMSC-CM) could promote tissue regeneration, including hair regeneration, more effectively than media from adipose tissue-derived stem cells. The DaMSC-CM contained novel round vesicles, approximately 120 nm in diameter, which could regulate gene expression related to tissue renewal, such as Wnt-3a, Wnt-10b, and LEF-1. These findings suggest that DaMSC-CM and its secretory vesicles could have therapeutic applications for tissue regeneration. The study focused on cellular and molecular mechanisms and did not involve human subjects.