From a Stem-Cell-Centered to a Niche-Centered View: The Core Role of Collagen Networks in Hair Loss and Hair Follicle Miniaturization
May 2026
in “
Frontiers in Cell and Developmental Biology
”
collagen networks hair follicle miniaturization alopecia hair follicle stem cells HFSCs progenitor cells niche identity basement membrane integrity adhesion apparatuses fibrillar organization mechanical set-points dynamic remodeling windows androgen-biased remodeling inflammation signal–structure mismatch hair loss hair thinning baldness stem cells collagen
Studysummary In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.
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