Basement Membrane Changes in Lichen Planopilaris

    June 2009 in “ Journal of the European Academy of Dermatology and Venereology ”
    Khitam Al‐Refu, Mark Goodfield
    TLDR Basement membrane changes in lichen planopilaris cause scarring and permanent hair loss.
    The study investigated basement membrane zone (BMZ) alterations in lichen planopilaris (LPP), an inflammatory disease causing cicatricial alopecia, using skin biopsies from 6 LPP patients and 6 controls. Immunohistochemistry revealed significant differences in the localization and staining of hemidesmosome, laminin, and collagen components in inflamed follicular epithelium compared to uninvolved areas. Hemidesmosome-associated complexes were weak and discontinuous, while laminin-5, type IV collagen, and type VII collagen showed disrupted, non-linear expression with projections into the dermis. These BMZ changes likely contributed to abnormal follicular healing, leading to irreversible hair loss and scarring in LPP.
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      in Research/Science  95 upvotes 9 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.
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      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Research/Science  56 upvotes 8 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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