A Stretch-Responsive Fibroblast Program Promotes Epidermal Stem Cell Self-Renewal During Skin Expansion

    June 2026 in “ Nature Communications ”
    Caroline Aguilera Stewart, Ceyhun Alar, Gaia Andrea Gozza … Mariaceleste Aragona
    Studysummary This study found that in stretch-mediated tissue expansion, fibroblasts adopt an embryonic-like, low-collagen state that enhances epidermal stem cell renewal, supporting coordinated skin expansion crucial for reconstructive surgeries.
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    Research cited in this study 22

    1. Fibroblast Bioelectric Signaling Drives Hair Growth Cell · 2025
    2. The Mechanotransducer Piezo1 Coordinates Metabolism and Inflammation to Promote Skin Growth Nature Communications · 2025
    3. Mechanical Forces Across Compartments Coordinate Cell Shape and Fate Transitions to Generate Tissue Architecture Nature cell biology · 2024
    4. The Extracellular Matrix Dictates Regional Competence for Tumor Initiation Nature · 2023
    5. Lineage Commitment of Dermal Fibroblast Progenitors Is Controlled by Kdm6b-Mediated Chromatin Demethylation The EMBO Journal · 2023
    6. Molecular and Spatial Landmarks of Early Mouse Skin Development Developmental cell · 2023
    7. Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging Nature Aging · 2023
    8. Fibroblast Heterogeneity in Healthy and Wounded Skin Cold Spring Harbor Perspectives in Biology · 2022
    9. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    10. Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells Nature Communications · 2021
    11. Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts Experimental Dermatology · 2020
    12. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    13. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    14. Macrophages Are Necessary for Skin Regeneration During Tissue Expansion Journal of Translational Medicine · 2019
    15. Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018
    16. Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing Molecular Systems Biology · 2018
    17. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    18. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    19. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    20. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    21. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    22. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011