Fibroblast Bioelectric Signaling Drives Hair Growth

    August 2025 in “ Cell ”
    Daoming Chen, Yu Zhou, Wenbo Wu … Ting Chen
    Studysummary Fibroblast bioelectric signaling can promote hair growth and may help treat hair loss.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 32

    1. Intermittent Fasting Triggers Interorgan Communication To Suppress Hair Follicle Regeneration Cell · 2024
    2. Essential Role of Macrophages in Contact Hypersensitivity-Induced Hair Regeneration Journal of Investigative Dermatology · 2024
    3. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    4. Current Understanding and Treatment of Sex Hormone-Related Hair Diseases Dermatologica Sinica · 2023
    5. Consumption of Fish Oil High-Fat Diet Induces Murine Hair Loss via Epidermal Fatty Acid Binding Protein in Skin Macrophages Cell reports · 2022
    6. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    7. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022
    8. Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis Cell Stem Cell · 2021
    9. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021
    10. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    11. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    12. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    13. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018
    14. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    15. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    16. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    17. CD133-Positive Dermal Papilla-Derived Wnt Ligands Regulate Postnatal Hair Growth Biochemical Journal · 2016
    18. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    19. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    20. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    21. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    22. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    23. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    24. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    25. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    26. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    27. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    28. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    29. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    30. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    31. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    32. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    6. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000