The Mechanotransducer Piezo1 Coordinates Metabolism and Inflammation to Promote Skin Growth

    July 2025 in “ Nature Communications ”
    Yingchao Xue, Elizabeth Winnicki, Zhaoxu Zhang … Luis A. Garza
    Studysummary In this study using mice, researchers found that the Piezo1 channel regulates metabolic changes and immune cell infiltration during skin growth under tension, with altered expression of glycolysis-related genes and increased macrophage activity observed in stretched skin.
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    Research cited in this study 6

    1. Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis Cell Stem Cell · 2021
    2. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    3. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    4. Macrophages Are Necessary for Skin Regeneration During Tissue Expansion Journal of Translational Medicine · 2019
    5. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    6. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015