TLDR Understanding how skin cells react to pressure can help diagnose and manage pressure-related skin disorders.
This review explores the pathological effects of mechanical pressure on skin at the cellular level, highlighting how different skin cells respond to such stimuli. Fibroblasts, keratinocytes, mast cells, melanocytes, adipocytes, and stem cells each play distinct roles in sensing and reacting to pressure, which can lead to pathological changes like ischemia, chronic inflammation, and necrosis. The study emphasizes the importance of understanding the diverse cellular responses and mechanotransduction pathways to better diagnose and manage skin disorders related to mechanical pressure.
1 citations
,
August 2023 in “The Journal of Pathology” Different types of skin fibroblasts have unique roles in skin health and disease.
1 citations
,
January 2023 in “Science Advances” The skin's microbiome helps hair regrow by boosting certain cell signals and metabolism.
65 citations
,
March 2018 in “Journal of Dermatological Science” Skin problems can be caused or worsened by physical forces and pressure on the skin.
18 citations
,
August 2017 in “PLOS ONE” Skin and its underlying fat layer act together to resist mechanical stress, and reinforcing this composite structure may help more with anti-aging than just strengthening the skin alone.
23 citations
,
April 2016 in “American Journal of Pathology” The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.
1235 citations
,
December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
1 citations
,
March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.
3 citations
,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.
Dermal stem cells help regenerate hair follicles and heal skin wounds.
349 citations
,
January 2005 in “The FASEB journal” Human skin can make serotonin and melatonin, which help protect and maintain it.
40 citations
,
January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
88 citations
,
July 2019 in “International Journal of Molecular Sciences” Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.
