Positively Charged Chitosan-Dissolving Microneedles Promote Follicular Accumulation of Finasteride Nanocrystals to Treat Androgenetic Alopecia

    Jingru Zhao, Hong Xiang, Yurong Liu, Xiaoqing Miao
    TLDR A new microneedle system effectively delivers finasteride to treat hair loss.
    The study presents a novel approach to treating androgenetic alopecia (AGA) by developing a three-tiered nano-drug delivery system using finasteride nanocrystals (FIN-NCs) stabilized with chitosan (CS) and delivered via dissolving microneedles (MNs). This system aims to enhance local drug treatment efficiency by targeting multiple therapeutic pathways, including inhibiting 5α-reductase activity, promoting hair follicle regeneration, and improving the microenvironment of hair follicles. The CS-stabilized FIN-NCs showed significant therapeutic efficacy in vivo, with improved drug stability, solubility, and retention in the skin, while minimizing systemic absorption and adverse effects. The study highlights the potential of this innovative delivery platform to provide an effective local treatment for AGA.
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