Experimental and Theoretical Studies on the Interaction of Finasteride with Chitosan-Based Nanoniosomes

January 2024 in “ Journal of molecular structure ”

Maedeh Pishnamazi, Shahad Mohammed Dhiaa, Rahmatollah Emadi, Seyed Abbas Shahrtash, Mohammad Reza Jamali, Jupinder Kaur, Alireza Soltani

finasteride chitosan nanoniosomes micellar vesicular nano-formulation niosome vesicular nano-formulation tween 80 squalene span 85 carbonyl group UV-Vis absorption spectra FIN UV-Vis

TLDR The new finasteride delivery system using chitosan-based nanoniosomes shows promise for prostate cancer prevention.

The study successfully developed and characterized a novel micellar/niosome vesicular nano-formulation for delivering finasteride (FIN) nanoparticles in oral drug delivery systems. The formulation involved the use of chitosan, tween 80, squalene, and span 85, and was optimized for enhanced drug solubility and stability. FT-IR analysis indicated the involvement of the carbonyl group in complex formation, and UV-Vis absorption spectra confirmed the successful encapsulation of FIN. This nano-formulation shows promise for improving the therapeutic effectiveness of FIN by enhancing its solubility and stability.

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