Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

    January 2024 in “ Saudi pharmaceutical journal ”
    Muneeba Akhtar, Muhammad Zaman, Ahsan Zamir Siddiqi, Hasan Ali, Rahima Khan, Muhammad Nadeem Alvi, Muhammad Hammad Butt, Fatma M. El‐Demerdash, Dalal Nasser Binjawhar, Amany A. Sayed, Ahmed E. Altyar, Mohamed M. Abdel-Daim
    Image of study
    TLDR The study successfully formulated and optimized a bilayer tablet combining Tamsulosin and Finasteride using response surface methodology.
    The study focused on formulating and optimizing a bilayer tablet with Tamsulosin (sustained release) and Finasteride (immediate release) using a response surface methodology. The tablets were prepared by direct compression, with 11 formulations for Tamsulosin and 9 for Finasteride. The drug release, evaluated using the in-vitro USP dissolution method, was found to be concentration dependent and best explained by Korsmeyer–Peppa kinetics. The mechanism of drug release was determined to be an anomalous diffusion mechanism or diffusion coupled with erosion. The most successful formulation had a desirability of 0.9987, indicating the effectiveness of the response surface methodology approach in formulating and optimizing the bilayer combination tablet.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 18 results

      community 7 years finasteride + 2 year dutasteride - Experience

      in Progress Pictures  15 upvotes 8 months ago
      A 35-year-old started finasteride in 2014 for hair loss and maintained hair density for 7 years, occasionally using ketoconazole shampoo. Switched to dutasteride in 2022 due to increased hair fall, experimented with dosages, and found a combination with tamsulosin effective despite initial adverse reactions.

      community 3.5 years progress. Oral Fin + Topical Min

      in Progress Pictures  20 upvotes 1 year ago
      The user shared a 3.5-year hair loss treatment journey, starting with daily finasteride and oral minoxidil, then switching to finasteride 4 times a week and daily topical minoxidil. After about 2 years and 9 months, they added Dutasteride and Tamsulosin Hydrochloride to their regimen, but reduced the frequency due to side effects, and are currently satisfied with the results.

      community Are they going to Ban Finasteride in the EU ?

      in Finasteride/Dutasteride  68 upvotes 1 month ago
      There is concern about a potential ban on finasteride in the EU, but many believe it is unlikely unless serious side effects are found. Users rely on finasteride for hair loss and other health benefits, and a petition has been created to oppose any restrictions.

      community People who tolerate dut better than fin?

      in Finasteride/Dutasteride  32 upvotes 1 month ago
      Dutasteride may have fewer side effects than finasteride, with some users experiencing better hair maintenance. Experiences vary, with some preferring dutasteride for fewer side effects, while others see no significant hair improvement.

    Similar Research

    5 / 249 results