Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

January 2024 in “ Saudi pharmaceutical journal ”

Muneeba Akhtar, Muhammad Zaman, Ahsan Zamir Siddiqi, Hasan Ali, Rahima Khan, Muhammad Nadeem Alvi, Muhammad Hammad Butt, Fatma M. El‐Demerdash, Dalal Nasser Binjawhar, Amany A. Sayed, Ahmed E. Altyar, Mohamed M. Abdel-Daim

Tamsulosin Finasteride bilayer tablet sustained release immediate release response surface methodology direct compression in-vitro USP dissolution method Korsmeyer–Peppa kinetics anomalous diffusion mechanism diffusion coupled with erosion Propecia

TLDR The study successfully formulated and optimized a bilayer tablet combining Tamsulosin and Finasteride using response surface methodology.

The study focused on formulating and optimizing a bilayer tablet with Tamsulosin (sustained release) and Finasteride (immediate release) using a response surface methodology. The tablets were prepared by direct compression, with 11 formulations for Tamsulosin and 9 for Finasteride. The drug release, evaluated using the in-vitro USP dissolution method, was found to be concentration dependent and best explained by Korsmeyer–Peppa kinetics. The mechanism of drug release was determined to be an anomalous diffusion mechanism or diffusion coupled with erosion. The most successful formulation had a desirability of 0.9987, indicating the effectiveness of the response surface methodology approach in formulating and optimizing the bilayer combination tablet.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

48 citations , January 2017 in “Skin Pharmacology and Physiology”

Finasteride-loaded nanoparticles may help treat alopecia.

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Similar Research

6 / 332 results

research Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

12 citations , July 2020 in “International Journal of Pharmaceutics”

Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.

research Efficacy Observation of Tamsulosin Combined with Finasteride on Delaying and Preventing the Progression of BPH

January 2011

Tamsulosin and finasteride together effectively slow down and prevent BPH progression.

research Efficacy of Combination of Tamsulosin and Finasteride on Urinary Symptoms and IPSS Score for Elderly Patients with BPH

January 2014 in “Hebei yixue”

Combining tamsulosin and finasteride effectively improves urinary symptoms in elderly BPH patients.

research Recognizing and Treating Undiagnosed Erectile Dysfunction in Patients Presenting With Lower Urinary Tract Symptoms

December 2016 in “The journal of sexual medicine”

Many patients with lower urinary tract symptoms also have undiagnosed erectile dysfunction, which improves with treatment.

Second Derivative Spectrophotometric Method for Simultaneous Determination of Tamsulosin and Finasteride in Pharmaceutical Formulations

research Second Derivative Spectrophotometric Method for Simultaneous Determination of Tamsulosin and Finasteride in Pharmaceutical Formulations

2 citations , September 2012 in “Asian Journal of Pharmaceutical Analysis”

A method was created in 2012 to accurately and precisely measure tamsulosin and finasteride in medicine using second derivative spectrophotometric method.

research RP-HPLC Assay Method for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Pharmaceutical Dosage Form

1 citations , January 2012 in “Analytical chemistry, an Indian journal”

A reliable method was developed to accurately measure tamsulosin hydrochloride and finasteride in tablets.

Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

Research cited in this study

research Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

Related Community Posts Join

community Finasteride and Eye Problems: You’re Not Going Crazy

community Can I take only the dutasteride capsule from inside Duodart?

community Vitamin D - I was taking vitamin D last 6 month, my hair is back(4000UI daily)

community 7 years finasteride + 2 year dutasteride - Experience

community Dutasteride+Tamsulosin combination

community Almost 90 days. The hair gods taketh and now giveth.