Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

    January 2024 in “ Saudi pharmaceutical journal ”
    Muneeba Akhtar, Muhammad Zaman, Ahsan Zamir Siddiqi, Hasan Ali, Rahima Khan, Muhammad Nadeem Alvi, Muhammad Hammad Butt, Fatma M. El‐Demerdash, Dalal Nasser Binjawhar, Amany A. Sayed, Ahmed E. Altyar, Mohamed M. Abdel-Daim
    Image of study
    TLDR The study successfully formulated and optimized a bilayer tablet combining Tamsulosin and Finasteride using response surface methodology.
    The study focused on formulating and optimizing a bilayer tablet with Tamsulosin (sustained release) and Finasteride (immediate release) using a response surface methodology. The tablets were prepared by direct compression, with 11 formulations for Tamsulosin and 9 for Finasteride. The drug release, evaluated using the in-vitro USP dissolution method, was found to be concentration dependent and best explained by Korsmeyer–Peppa kinetics. The mechanism of drug release was determined to be an anomalous diffusion mechanism or diffusion coupled with erosion. The most successful formulation had a desirability of 0.9987, indicating the effectiveness of the response surface methodology approach in formulating and optimizing the bilayer combination tablet.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 24 results

      community 7 years finasteride + 2 year dutasteride - Experience

      in Progress Pictures  15 upvotes 1 year ago
      A 35-year-old started finasteride in 2014 for hair loss and maintained hair density for 7 years, occasionally using ketoconazole shampoo. Switched to dutasteride in 2022 due to increased hair fall, experimented with dosages, and found a combination with tamsulosin effective despite initial adverse reactions.

      community 3.5 years progress. Oral Fin + Topical Min

      in Progress Pictures  19 upvotes 1 year ago
      The user shared a 3.5-year hair loss treatment journey, starting with daily finasteride and oral minoxidil, then switching to finasteride 4 times a week and daily topical minoxidil. After about 2 years and 9 months, they added Dutasteride and Tamsulosin Hydrochloride to their regimen, but reduced the frequency due to side effects, and are currently satisfied with the results.

      community What to do if fin is still not working after 2.5 years

      in Finasteride/Dutasteride  22 upvotes 1 week ago
      The user is experiencing increased hair loss despite using finasteride and oral minoxidil and is hesitant to switch to dutasteride due to side effects and family planning concerns. Alternatives suggested include dutasteride, microneedling, and addressing stress or nutrient deficiencies.

    Similar Research

    5 / 258 results