Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

January 2024 in “ Saudi pharmaceutical journal ”

Muneeba Akhtar, Muhammad Zaman, Ahsan Zamir Siddiqi, Hasan Ali, Rahima Khan, Muhammad Nadeem Alvi, Muhammad Hammad Butt, Fatma M. El‐Demerdash, Dalal Nasser Binjawhar, Amany A. Sayed, Ahmed E. Altyar, Mohamed M. Abdel-Daim

Tamsulosin Finasteride bilayer tablet sustained release immediate release response surface methodology direct compression in-vitro USP dissolution method Korsmeyer–Peppa kinetics anomalous diffusion mechanism diffusion coupled with erosion Propecia

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Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary In this study, the researchers developed and optimized a bilayer tablet containing Tamsulosin and Finasteride, achieving sustained and immediate drug release with favorable release kinetics, including first-order and anomalous diffusion mechanisms, through in vitro testing.

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