Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

    January 2024 in “ Saudi pharmaceutical journal ”
    Muneeba Akhtar, Muhammad Zaman, Ahsan Zamir Siddiqi, Hasan Ali, Rahima Khan, Muhammad Nadeem Alvi, Muhammad Hammad Butt, Fatma M. El‐Demerdash, Dalal Nasser Binjawhar, Amany A. Sayed, Ahmed E. Altyar, Mohamed M. Abdel-Daim
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    TLDR The study successfully formulated and optimized a bilayer tablet combining Tamsulosin and Finasteride using response surface methodology.
    The study focused on formulating and optimizing a bilayer tablet with Tamsulosin (sustained release) and Finasteride (immediate release) using a response surface methodology. The tablets were prepared by direct compression, with 11 formulations for Tamsulosin and 9 for Finasteride. The drug release, evaluated using the in-vitro USP dissolution method, was found to be concentration dependent and best explained by Korsmeyer–Peppa kinetics. The mechanism of drug release was determined to be an anomalous diffusion mechanism or diffusion coupled with erosion. The most successful formulation had a desirability of 0.9987, indicating the effectiveness of the response surface methodology approach in formulating and optimizing the bilayer combination tablet.
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