Experimental Investigation on Finasteride Microparticles Formation via Gas Antisolvent Process

    January 2021 in “ Korean Journal of Chemical Engineering ”
    Mohammad Najafi, Nadia Esfandiari, Bizhan Honarvar, Zahra Arab Aboosadi
    TLDR Higher pressure significantly reduces Finasteride particle size.
    The study investigated the formation of Finasteride micro and nanoparticles using the gas-antisolvent method, focusing on the effects of pressure, temperature, and solute concentration on particle size. The Box-Behnken design and ANOVA results showed that pressure had the most significant impact on reducing particle size. The optimal conditions for achieving the smallest particles were a solute concentration of 10 mg/ml, a temperature of 308 K, and a pressure of 160 bar. Under these conditions, the mean particle size was reduced to 232.4 nm, as confirmed by various analytical techniques, compared to the original particle size of 55.6 nm.
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