Nailfold Capillaroscopy Alterations in Androgenetic Alopecia: A Cross-Sectional Study

    Lei Cao, Yajuan Wu, Yuanbo Huang, Zhong-Ming Li, Jing Zhu, Wenrong Xu, Lan Xu, Yanmin Jiang, Lu Yu, Lei Wang
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    TLDR Men with androgenetic alopecia, or hair loss, often have abnormal blood flow in their small blood vessels, which might be linked to inflammation and stress.
    The study involved 78 male patients with androgenetic alopecia and 78 healthy male controls, using nailfold capillaroscopy to examine microcirculation. The results showed that abnormalities such as avascular areas, dilated, bushy and bizarre capillaries, and capillary disorganization were significantly more frequent in patients with androgenetic alopecia. This suggests that microcirculation abnormalities may be involved in androgenetic alopecia. The study also found that changes indicative of hypoxia are more common in these patients, despite having a normal mean capillary density, possibly associated with systemic inflammation related to oxidative stress. However, the results may be biased due to the limited sample size and the presence of undiagnosed diseases in participants.
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