A Finasteride Patch for the Treatment of Androgenetic Alopecia: Study on Permeability Strategy Using Synthetic O-Acylmenthols and Ion-Pair

October 2024 in “ International Journal of Pharmaceutics ”

Hui Li, Peng Sun, Shuhan Liu, Liuyang Wang, Yang Zhang, Jie Liu, Liang Fang

finasteride androgenetic alopecia transdermal patch ion-pair O-acylmenthols chemical permeation enhancers pharmacokinetics pharmacodynamics permeability enhancement synthetic FIN-CA MT-C6 pressure-sensitive adhesive 25-AAOH FIN AGA CPEs

Studysummary This study aimed to develop a new transdermal patch for treating androgenetic alopecia using finasteride, combined with chemical permeation enhancers to improve drug delivery through the skin, but results of pharmacokinetics and pharmacodynamics evaluations are not reported.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Development and Evaluation of Finasteride Niosomes Targeting Hair Follicles for Androgenic Alopecia Management

July 2023 in “Journal of Drug Delivery Science and Technology”

This study found that finasteride niosomes may enhance hair follicle drug accumulation and promote hair regeneration in androgenetic alopecia mice more effectively than current finasteride formulations.

research Androgenetic Alopecia: Therapy Update

May 2023 in “Drugs”

This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.

research Natural Products for Male Androgenetic Alopecia

2 citations , January 2022 in “Dermatologic Therapy”

Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.

research Novel Tip-Loaded Dissolving and Implantable Microneedle Array Patches for Sustained Release of Finasteride

23 citations , July 2021 in “International Journal of Pharmaceutics”

This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.

Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

research Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

3 citations , April 2021 in “Journal of Medicinal Chemistry”

This study suggests that finasteride may inhibit the enzyme PNMT, potentially contributing to its sexual and psychological side effects.

research Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers

5 citations , May 2020 in “Pharmaceutical Research”

This study found that short durations of heat and specific chemical penetration enhancers significantly improved the delivery of finasteride to human scalp skin and hair follicles.

research Androgenetic Alopecia: Effects of Oral Finasteride on Hormone Profile, Reproduction, and Sexual Function

10 citations , February 2020 in “Endocrine”

This study found that finasteride treatment in males with androgenetic alopecia was linked to significant changes in sperm parameters and increased testosterone levels, but no sexual dysfunction was observed, and sperm parameters returned to baseline after treatment stopped.

research Development of Finasteride Polymer Microspheres for Systemic Application in Androgenic Alopecia

6 citations , March 2019 in “International Journal of Molecular Medicine”

This study found that finasteride-loaded microspheres effectively treated androgenic alopecia in a mouse model, showing similar hair growth effects to orally-administered finasteride.

research Preformulation Studies of Finasteride to Design Matrix Systems for Topical Delivery

14 citations , August 2018 in “Journal of Pharmaceutical and Biomedical Analysis”

This study found that finasteride maintained chemical and physical stability in various excipient mixtures, which may guide the development of stable topical delivery systems.

research Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice

36 citations , February 2017 in “BMC Complementary and Alternative Medicine”

In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.

research Structural Characterization of Polymorphs and Molecular Complexes of Finasteride

17 citations , January 1999 in “Journal of Molecular Structure”

This study determined the molecular structure of finasteride and its related crystalline forms, highlighting different hydrogen-bond interactions and structural configurations in various crystalline complexes.