Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers

May 2020 in “ Pharmaceutical Research ”

H.A. Farah, Matthew A. Brown, William J. McAuley

finasteride heat chemical penetration enhancers human scalp skin hair follicles androgenetic alopecia topical finasteride Propecia

TLDR Heat and chemicals improve finasteride delivery to scalp and hair follicles, potentially enhancing treatment for hair loss.

The study investigated the use of heat and chemical penetration enhancers to improve the delivery of finasteride to human scalp skin and hair follicles. The results showed that short durations of externally applied heat significantly increased finasteride penetration into human scalp skin after 24 hours. The use of short durations of heat in combination with specific chemical penetration enhancers was able to increase the delivery of finasteride to human scalp skin and provide focused drug delivery to the hair follicles. The study suggests that this approach could be used to enhance the efficacy of topical finasteride for the treatment of androgenetic alopecia.

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research Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers

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Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers

Research cited in this study

research Heat Enhanced Follicular Delivery of Isotretinoin to the Skin

research Clinical Efficacy of Oral Administration of Finasteride at a Dose of 2.5 mg/Day in Women with Female Pattern Hair Loss

research Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals

research An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

research Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia

research Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

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research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

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