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Research

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research Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice

60 citations , February 1992 in “British Journal of Dermatology”

In this study, serum from patients with alopecia areata or universalis did not affect hair growth in transplanted scalp skin grafts on nude mice, despite increased deposition of immunoreactants.

research Time and depth resolved visualisation of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin

36 citations , July 2004 in “Journal of Controlled Release”

This study demonstrates that confocal laser scanning microscopy can effectively visualize the rapid diffusion and penetration pathway of a dye into the hair follicle in fresh human scalp skin.

research Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers

5 citations , May 2020 in “Pharmaceutical Research”

This study found that short durations of heat and specific chemical penetration enhancers significantly improved the delivery of finasteride to human scalp skin and hair follicles.

research Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin

June 2024

This study suggests that topically applied thyroid hormones T3 and T4 promote hair growth on human scalp tissues ex vivo, highlighting potential therapeutic use for hair loss conditions like androgenetic alopecia.

research Hair follicle markers, expression and modulation: Studies on human scalp skin grafts

February 2010 in “Journal of the American Academy of Dermatology”

Activating cAMP and ATP improves hair growth and strength.

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Community Join

5 / 1000+ results

community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 10 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

community Going bald is a genuine health issue.

100 upvotes 3 weeks ago

Bald people have a higher risk of skin cancer, especially on the scalp, and wearing a hat is suggested as a solution. Hair loss treatments like Minoxidil, finasteride, and RU58841 are not mentioned in this conversation.

community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 2 years ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Using topicals after hair transplant if safe to do so

5 upvotes 4 months ago

After a hair transplant, it's advised to stop using RU58841 and minoxidil to avoid irritation, resuming them 25-30 days post-surgery if the scalp is healed. The user is currently using finasteride, minoxidil, and RU58841, but there are concerns about the safety and efficacy of RU58841 in humans.

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Learn

10 / 23 results

learn Fluocinolone

Is Fluocinolone a treatment for hair loss itself or just for calming scalp irritation? Fluocinolone acetonide is a prescription corticosteroid approved for inflammatory skin conditions, not for hair loss; no published human trial has measured hair regrowth with it, so at most it may help indirectly by calming an inflamed scalp.

learn Latanoprost

Can latanoprost be safely applied to the scalp, or is it only for eyelashes? Latanoprost is not approved for use on the scalp and its safety there has not been established: the only human scalp evidence is one 24-week pilot trial in 16 men, and clinicians flag irritation, skin darkening and unknown absorption over a large area as open risks.

learn capsicum

How does capsicum improve scalp circulation and boost growth? Capsaicin dilates blood vessels through TRPV1 activation, so capsicum is expected to raise scalp blood flow, but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn sh-Polypeptide-7

learn Epidermal Growth Factor

learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Bicalutamide

What results can you expect from using bicalutamide on your scalp? There is no published human study of bicalutamide applied to the scalp for hair loss, no licensed topical product and no established dose, so no result can be predicted from it. The evidence that exists is for the oral tablet in women, which is a prescription drug requiring liver monitoring and contraindicated in pregnancy.

learn Rapamycin

Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

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Clinics

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All 12 clinic results →

Experts

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24
Trichologist
Kirsten J. Scalp
Greenville, SC, United States

Kirsten J. Scalp