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research 3P's of Valproate: Pharmacokinetic, Pharmacodynamic, and Pharmacogenomic Updates

June 2023 in “International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science”

New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.

research Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics

16 citations , January 2010 in “Drug Metabolism and Pharmacokinetics”

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

research A Finasteride Patch for the Treatment of Androgenetic Alopecia: Study on Permeability Strategy Using Synthetic O-Acylmenthols and Ion-Pair

October 2024 in “International Journal of Pharmaceutics”

The finasteride patch effectively treats hair loss by enhancing skin absorption.

research Modeling the Pharmacodynamics of Nandrolone Doping Drug and Implications for Anti-Doping Testing

October 2020 in “System Dynamics Review”

The document concludes that finasteride can reduce nandrolone detection in doping tests, suggesting frequent testing and setting metabolite level thresholds for detection.

research Clinical Pearls Addressing Hair Growth and Loss in Transgender Patients on Hormone Replacement Therapy

March 2025 in “Dermatology Online Journal”

Dermatologists should guide transgender patients on effective hair growth and loss treatments during hormone therapy.

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community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 1 year ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

Fuzzasteride in Research 489 upvotes 1 year ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community DHT reduction in the scalp for all doses of dutasteride is now available.

in Finasteride/Dutasteride 357 upvotes 10 months ago

Higher doses of dutasteride reduce scalp DHT more effectively than finasteride, but have diminishing returns after 3mg daily and may cause more side effects. Combining dutasteride with topical minoxidil can enhance results, but using both finasteride and dutasteride together is unnecessary.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 113 upvotes 1 year ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community When to switch from finasteride to dutasteride and how long to wait for dutasteride to build up

baldbutnotbold in Finasteride 137 upvotes 3 months ago

The user is considering switching from finasteride to dutasteride for hair loss treatment and is unsure when to stop finasteride. Dutasteride takes about 15 days to reach significant DHT suppression compared to finasteride.

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