Chitosan and Its Amphiphilic Derivative Nanoparticles Loaded with Minoxidil for Induction of Hair Growth: In Vitro and In Vivo Evaluation

The study "Chitosan and its amphiphilic derivative nanoparticles loaded with Minoxidil for induction of hair growth: In vitro and in vivo evaluation" explores the use of Methylated Aminobenzyl Carboxymethyl Chitosan (MCS), an amphiphilic derivative of chitosan (CS), for the delivery of Minoxidil (MIN), a common treatment for Androgenetic Alopecia (AA). The researchers formulated nanoparticles using MCS and assessed their ability to deliver MIN transdermally to enhance hair growth while maintaining a sustained release pattern. The results showed that MCS could produce a more sustained release formulation compared to CS. The amphiphilic chitosan derivative nanoparticles were non-toxic to cells and showed higher efficiency compared to the commercial formulation. However, CS was found to be a preferable option for the delivery of MIN due to more complete release of the active molecule.