Minoxidil And Its Use In Hair Disorders: A Review

    Poonkiat Suchonwanit, Sasima Thammarucha, Kanchana Leerunyakul
    Studysummary This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on dovepress.com →
    Discuss this study in the Community →

    Research cited in this study 81

    1. The Effect of Topical Minoxidil Treatment on Follicular Sulfotransferase Enzymatic Activity PubMed · 2019
    2. Efficacy and Safety of Bimatoprost 0.01% for the Treatment of Eyebrow Hypotrichosis Dermatologic surgery · 2019
    3. Low-Dose Daily Aspirin Reduces Topical Minoxidil Efficacy in Androgenetic Alopecia Patients Dermatologic Therapy · 2018
    4. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study American Journal of Clinical Dermatology · 2018
    5. Alopecia in Association with Malignancy: A Review American Journal of Clinical Dermatology · 2018
    6. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    7. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
    8. Loose Anagen Hair Syndrome: Treatment with Systemic Minoxidil Characterized by Marked Hair Color Change Australasian Journal of Dermatology · 2018
    9. Therapeutic Potential of Bimatoprost for the Treatment of Eyebrow Hypotrichosis Drug Design Development and Therapy · 2018
    10. Use of Minoxidil Sulfate Versus Minoxidil Base in Androgenetic Alopecia Treatment: Friend or Foe? Skin appendage disorders · 2018
    11. Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase International Journal of Molecular Sciences · 2017
    12. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    13. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    14. Parietal Scalp Is Another Affected Area in Female Pattern Hair Loss: An Analysis of Hair Density and Hair Diameter Clinical, Cosmetic and Investigational Dermatology · 2017
    15. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    16. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    17. Minoxidil Dose Response Study in Female Pattern Hair Loss Patients Determined to Be Non-Responders to 5% Topical Minoxidil PubMed · 2017
    18. PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017
    19. Treating Alopecia Areata: Current Practices Versus New Directions American journal of clinical dermatology · 2016
    20. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    21. Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study PubMed · 2016
    22. Treatment of Monilethrix with Oral Minoxidil JAAD case reports · 2016
    23. Efficacy and Safety of Minoxidil 3% Lotion for Beard Enhancement: A Randomized, Double-Masked, Placebo-Controlled Study The Journal of Dermatology · 2016
    24. Factors Affecting the Severity of Central Centrifugal Cicatricial Alopecia International Journal of Dermatology · 2016
    25. Frontal Fibrosing Alopecia Treatment Options Intractable & Rare Diseases Research · 2016
    26. Treatment of Permanent Chemotherapy-Induced Alopecia with Low Dose Oral Minoxidil Australasian Journal of Dermatology · 2015
    27. Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia Dermatologic Therapy · 2014
    28. Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia Dermatologic Therapy · 2014
    29. Minoxidil 5% Solution for Topical Treatment of Loose Anagen Hair Syndrome Pediatric Dermatology · 2014
    30. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    31. Minoxidil 2% Lotion for Eyebrow Enhancement: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Comparative Study The Journal of Dermatology · 2013
    32. Efficacy and Safety of Bimatoprost 0.03% Versus Minoxidil 3% in Enhancement of Eyebrows: A Randomized, Double-Blind, Split-Face Comparative Study Journal of dermatology · 2012
    33. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    34. A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 2011
    35. Monilethrix Treated with Minoxidil International Journal of Immunopathology and Pharmacology · 2011
    36. Identification of Transcriptional Targets of Wnt/β-Catenin Signaling in Dermal Papilla Cells of Human Scalp Hair Follicles: EP2 Is a Novel Transcriptional Target of Wnt3a Journal of Dermatological Science · 2010
    37. Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer British journal of dermatology/British journal of dermatology, Supplement · 2009
    38. Minoxidil Topical Foam: A New Kid on the Block International journal of trichology · 2009
    39. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    40. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    41. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    42. A Randomized, Placebo-Controlled Trial of 1% Topical Minoxidil Solution in the Treatment of Androgenetic Alopecia in Japanese Women PubMed · 2007
    43. Traction Alopecia: 2% Topical Minoxidil Shows Promise. Report of Two Cases Journal of The European Academy of Dermatology and Venereology · 2006
    44. Frontal Fibrosing Alopecia in Postmenopausal Women Journal of The American Academy of Dermatology · 2004
    45. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    46. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    47. The Effects of Minoxidil, 1% Pyrithione Zinc, and a Combination of Both on Hair Density: A Randomized Controlled Trial British Journal of Dermatology · 2003
    48. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    49. Recurrent Missense Mutations in the Hair Keratin Gene HHb6 in Monilethrix Clinical and Experimental Dermatology · 2003
    50. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    51. Telogen Effluvium: Causes, Diagnosis, and Treatment Clinical and Experimental Dermatology · 2002
    52. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    53. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    54. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    55. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    56. The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall British Journal of Dermatology · 1999
    57. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    58. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    59. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    60. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    61. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    62. Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia Annals of Oncology · 1994
    63. Relative Influence of Ethanol and Propylene Glycol Cosolvents on Deposition of Minoxidil into the Skin Journal of Pharmaceutical Sciences · 1994
    64. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992
    65. Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration Journal of Investigative Dermatology · 1992
    66. The Use of Minoxidil to Prevent Alopecia During Chemotherapy for Gynecologic Malignancies PubMed · 1991
    67. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    68. Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1990
    69. Extensive Alopecia Areata: Results of Treatment with 3% Topical Minoxidil Cleveland Clinic Journal of Medicine · 1989
    70. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989
    71. Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia Clinics in Dermatology · 1988
    72. Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture Biochemical Pharmacology · 1988
    73. Evaluation of Oral Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1987
    74. Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata Journal of The American Academy of Dermatology · 1987
    75. Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata Journal of The American Academy of Dermatology · 1987
    76. Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy Journal of The American Academy of Dermatology · 1987
    77. Immunohistochemical Characterization of the Cellular Infiltrate in Severe Alopecia Areata Before and After Minoxidil Treatment Dermatology · 1987
    78. Topical Minoxidil Therapy and Hair Regrowth Archives of Dermatology · 1985
    79. Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use Drugs · 1981
    80. Pharmacology and Pharmacokinetics of Minoxidil Journal of Cardiovascular Pharmacology · 1980
    81. Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory PubMed · 1977

    Related research 9

    1. Randomized Trial of Microneedling Combined With 2% Minoxidil Topical Solution for the Treatment of Female Pattern Hair Loss in a Chinese Population Journal of Cosmetic Dermatology · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients Journal of The American Academy of Dermatology · 2021
    4. Role of Low Dose Oral Minoxidil in the Treatment of Hair Loss: A Review Cosmoderma · 2021
    5. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    6. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    7. The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review PubMed · 2019
    8. Generalized Hypertrichosis After Treatment With Topical Minoxidil Clinical and Experimental Dermatology · 1994
    9. Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica Drugs · 1987