Minoxidil 5% Solution for Topical Treatment of Loose Anagen Hair Syndrome

In 2014, a 2-year-old girl diagnosed with loose anagen hair syndrome (LAHS) was treated with a tapering regime of minoxidil 5% solution over 28 months. The treatment resulted in significant clinical improvement with no adverse effects. The patient initially presented with excessive hair loss, leading to sparse hair since birth. After six months of daily minoxidil 5% solution, significant improvement in hair density was noted. Continued improvement was observed at 6, 12, and 20 months, with the solution reduced to thrice, twice, and once a week, respectively. After 28 months, her hair was visibly darker and denser, and treatment was discontinued. No adverse effects were noted throughout the treatment and follow-up period. This was the first description of a tapering regime of topical minoxidil 5% solution resulting in significant clinical improvement and no adverse effects in a patient with LAHS. The authors recommended this as a first-line treatment of LAHS, regardless of severity, to hasten the resolution of clinical symptoms in patients.