Treating Alopecia Areata: Current Practices Versus New Directions

October 2016 in “ American journal of clinical dermatology ”

Aditya K. Gupta, Jessie Carviel, William Abramovits

alopecia areata corticosteroids immunosuppressants Janus kinase inhibitors tofacitinib ruxolitinib platelet-rich plasma excimer lasers JAK inhibitors PRP

TLDR New treatments like JAK inhibitors show promise for reversing alopecia areata.

The document reviewed treatments for alopecia areata, comparing traditional methods like corticosteroids and immunosuppressants with newer therapies such as Janus kinase (JAK) inhibitors (tofacitinib and ruxolitinib), which showed promise in reversing the condition by targeting immune pathways. Some patients experienced significant hair regrowth with JAK inhibitors. Other emerging treatments included platelet-rich plasma (PRP) therapy and excimer lasers, though their effectiveness varied. The review highlighted the necessity for ongoing research to improve these therapies and understand their long-term effects.

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research Successful Treatment of Pediatric Alopecia Areata of the Scalp Using Topical Bimatoprost

14 citations , July 2016 in “Pediatric Dermatology”

A 9-year-old girl with alopecia areata had successful hair regrowth using bimatoprost after other treatments failed.

research Efficacy of Tofacitinib in Treatment of Alopecia Universalis in Two Patients

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Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.

research Treatment Options for Alopecia

17 citations , August 2015 in “Expert Opinion on Pharmacotherapy”

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28 citations , July 2015 in “Dermatologic therapy”

The combined therapy was effective and safe for children with severe alopecia areata.

research Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience

61 citations , January 2015 in “Indian Journal of Plastic Surgery”

Platelet-rich plasma treatment could potentially be an effective way to treat chronic alopecia areata with minimal side effects.

research Bimatoprost Versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study

36 citations , January 2015 in “Dermatology”

Bimatoprost was found to be safer and more effective than mometasone furoate for treating scalp hair loss.

research Platelet-Rich Plasma as a Potential Treatment for Noncicatricial Alopecias

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308-nm excimer laser therapy helps regrow hair in alopecia areata.

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research Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients

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research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

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Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

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research Limited Effectiveness of Platelet-Rich Plasma Treatment on Chronic Severe Alopecia Areata

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Platelet-rich plasma treatment is not very effective for chronic severe alopecia areata.

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research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

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research Alopecia Areata: A New Treatment Plan

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Methylprednisolone pulse therapy works best for recent and specific types of severe alopecia areata.

research Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers

13 citations , June 2010 in “Journal of dermatological treatment”

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research Successful Use of Bimatoprost in the Treatment of Eyelash Alopecia

15 citations , June 2010 in “Clinical and Experimental Dermatology”

Bimatoprost helped a girl grow her eyelashes back quickly and without serious side effects.

research Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata

52 citations , March 2010 in “British Journal of Dermatology”

Alopecia areata shows a unique type 1 interferon signature, suggesting potential treatment by targeting this pathway.

research Alopecia Areata Update

244 citations , February 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Topical Immunotherapy in Alopecia Areata

45 citations , January 2010 in “International journal of trichology”

Topical immunotherapy, especially with DPCP, is effective for treating severe alopecia areata.

research Bimatoprost in the Treatment of Eyelash Universalis Alopecia Areata

37 citations , January 2010 in “International Journal of Trichology”

Bimatoprost helped eyelash growth in nearly half of the patients with a type of eyelash hair loss.

research 308-nm Excimer Laser for the Treatment of Alopecia Areata in Children

79 citations , September 2009 in “Pediatric dermatology”

The 308-nm Excimer laser is effective and safe for treating patchy alopecia areata in children.

research Instilled Bimatoprost Ophthalmic Solution in Patients with Eyelash Alopecia Areata

30 citations , September 2009 in “Journal of the American Academy of Dermatology”

Bimatoprost is safe but not effective for severe eyelash loss from alopecia areata, possibly helping those with less loss.

research Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro

51 citations , April 2009 in “Journal of dermatological science”

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

research Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

55 citations , April 2009 in “Journal of The American Academy of Dermatology”

Topical latanoprost and bimatoprost eye solutions don't help eyelash growth in people with alopecia areata.

research Lack of Response of Alopecia Areata to Pimecrolimus Cream

26 citations , July 2007 in “Clinical and experimental dermatology”

Pimecrolimus cream is not effective for treating alopecia areata.

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations , January 2006 in “Autoimmunity Reviews”

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

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29 citations , January 2004 in “Experimental Dermatology”

Topical anthralin helped regrow hair in mice with a condition similar to human alopecia.

research Guidelines for the Management of Alopecia Areata

182 citations , October 2003 in “British Journal of Dermatology”

The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.

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research Effectivity of Minoxidil as a Treatment for Alopecia Areata

January 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)”