Female Pattern Hair Loss: An Overview with Focus on the Genetics

June 2023 in “ Genes ”

Chao‐Chi Ho, Jeff Yi‐Fu Chen, Wen‐Li Hsu, Sebastian Yu, Wei-Chiao Chen, Szu‐Hao Chiu, Huiru Yang, Sheng-Yao Lin, Chieh‐Shan Wu

Female Pattern Hair Loss genetic factors inflammation nutrition hormonal factors topical treatments systemic treatments surgical interventions vitamin D nutritional supplements FPHL

Studysummary This review discusses the genetic differences between male and female pattern hair loss and highlights the uncertainty surrounding genetic factors in female pattern hair loss, but reports no clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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The Role of Hair Follicle Counts and Ratios in the Histopathological Assessment of Androgenic Alopecia, Alopecia Areata and Telogen Effluvium: Does Counting 'Count'?

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March 2023 in “Human Pathology”

This review found that while follicular hair counts and ratios assist in diagnosing non-scarring alopecia, they should be used alongside specific morphological features for accurate diagnosis.

research Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia

November 2022 in “Molecular Pharmaceutics”

This study found that intradermal injection of a cell-penetrating, AR-targeting asiRNA promoted hair growth and reduced androgen receptor expression in mouse models of androgenetic alopecia, suggesting its therapeutic potential.

research Female Pattern Hair Loss and Polycystic Ovarian Syndrome: More Than Just Hirsutism

1 citations , October 2022 in “Current Opinion in Endocrinology, Diabetes and Obesity”

This review discusses the diagnosis, management, and clinical challenges of female pattern hair loss in PCOS patients but reports no new clinical findings, highlighting the need for further research and multidisciplinary care.

research Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype

August 2022 in “Nutrients”

This ex vivo study found that hair follicles in female pattern hair loss exhibited nutrient insufficiency and dormant metabolism, but maintained nutrient uptake capability, suggesting potential benefits of nutritional supplementation as an adjunct therapy.

research Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

1 citations , July 2022 in “British Journal of Dermatology”

In this study, researchers identified key transcriptome changes in male androgenetic alopecia hair follicles, suggesting that HIF-1 pathway genes and Wnt pathway inhibitors could be potential therapeutic targets.

research Changes in the Expression of Smooth Muscle Cell-Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss

2 citations , June 2022 in “International Journal of Molecular Sciences”

This study found variable outcomes in hair loss treatment with autologous cell-based therapy using DSC cells, with certain gene markers showing inconsistent correlations with treatment efficacy.

research An Extract of Leontopodium Alpinum Inhibits Catagen Development Ex Vivo and Increases Hair Density In Vivo

1 citations , May 2022 in “International Journal of Cosmetic Science”

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research Topical Finasteride for Male and Female Pattern Hair Loss: Is It a Safe and Effective Alternative?

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This review found that topical finasteride has similar efficacy to oral finasteride in treating male and female pattern hair loss, with fewer systemic side effects, mainly causing localized scalp reactions like irritation and erythema.

research Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

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research Early Onset Female Pattern Hair Loss: A Case-Control Study for Analyzing Clinical Features and Genetic Variants

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research Prevalence of Female Pattern Hair Loss in Postmenopausal Women: A Cross-Sectional Study

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research Effects of Watercress Extract Fraction on R-Spondin 1-Mediated Growth of Human Hair

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research Randomized Clinical Trial of Low-Dose Oral Minoxidil for the Treatment of Female Pattern Hair Loss: 0.25 mg Versus 1 mg

3 citations , January 2022 in “Journal of The American Academy of Dermatology”

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research The Role of CYP19A1 and ESR2 Gene Polymorphisms in Female Androgenetic Alopecia in the Polish Population

October 2021 in “Postepy Dermatologii I Alergologii”

In this study, researchers found no significant association between selected CYP19A1 and ESR2 gene SNPs and female androgenetic alopecia in the Polish population studied.

research Role of Vitamin D in Hair Loss: A Short Review

14 citations , September 2021 in “Journal of Cosmetic Dermatology”

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research Evaluation of Susceptibility Genes and Loci Associated with Male Androgenetic Alopecia for Female-Pattern Hair Loss in a Chinese Han Population and a Brief Literature Review

1 citations , August 2021 in “Medical Science Monitor”

This study found no significant association between genetic loci linked to male androgenetic alopecia and female-pattern hair loss in a Chinese Han population, suggesting they are etiologically separate disorders.

research Urban-Rural Differences in the Prevalence of Female Pattern Hair Loss Among Secondary School Girls: A Cross-Sectional Study

1 citations , August 2021 in “Journal of Cosmetic Dermatology”

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research Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial

4 citations , February 2021 in “Journal of Cosmetic Dermatology”

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research The Inflammatory Aspect of Male and Female Pattern Hair Loss

9 citations , November 2020 in “Journal of Inflammation Research”

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Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

research Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

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11 citations , June 2020 in “Dermatologic Therapy”

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research Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

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research Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature

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research Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss

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9 citations , January 2019 in “American Journal of Dermatopathology”

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research New Drugs Under Investigation for the Treatment of Alopecias

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research Alopecia Areata: A Multifactorial Autoimmune Condition

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research Genetic and Molecular Aspects of Androgenetic Alopecia

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research GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

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research The Ovariectomized Mouse Simulates the Pathophysiology of Postmenopausal Female Pattern Hair Loss

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research Androgenetic Alopecia: A Review

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research Interventions for Female Pattern Hair Loss

21 citations , May 2016 in “The Cochrane library”

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research Assessment of Vitamin D Receptors in Alopecia Areata and Androgenetic Alopecia

20 citations , May 2016 in “Journal of Cosmetic Dermatology”

This study suggests that lower serum and tissue vitamin D receptor levels in alopecia areata and androgenetic alopecia patients may play a role in the pathogenesis of these hair diseases.

research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

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research Serum Vitamin D3 Level in Patients with Female Pattern Hair Loss

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research The Estrogen Receptor 2 (ESR2) Gene in Female-Pattern Hair Loss: Replication of Association with rs10137185 in German Patients

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25 citations , July 2013 in “Journal of Dermatological Science”

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research Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss

9 citations , November 2012 in “Archives of Dermatological Research”

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research Interventions for Female Pattern Hair Loss

35 citations , May 2012 in “Cochrane Database of Systematic Reviews”

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research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations , February 2012 in “British Journal of Dermatology”

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research Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

27 citations , October 2011 in “British Journal of Dermatology”

This study builds on previous findings by associating female pattern hair loss with gene polymorphisms related to oestrogen activity, suggesting oestrogen's role in the condition.

research Investigation of Variants of the Aromatase Gene (CYP19A1) in Female Pattern Hair Loss

15 citations , June 2011 in “British Journal of Dermatology”

This study observed a potential association between the CC genotype of rs4646 and female pattern hair loss, but the authors advise caution due to lack of experiment-wide significance and recommend replication.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations , April 2009 in “British Journal of Dermatology”

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