The Role of CYP19A1 and ESR2 Gene Polymorphisms in Female Androgenetic Alopecia in the Polish Population

October 2021 in “ Postepy Dermatologii I Alergologii ”

Adam Łukasik, Karolina Kozicka, Aleksandra Pisarek, Anna Wojas-Pelc

CYP19A1 ESR2 gene polymorphisms female androgenetic alopecia FAGA SNPs sex hormones androgenetic alopecia gene variations female pattern hair loss

TLDR No significant link was found between the studied genes and female hair loss in the Polish population.

The study investigated the association of 13 CYP19A1 and 11 ESR2 gene SNPs with female androgenetic alopecia (FAGA) in a Polish population, involving 117 patients with FAGA and 128 healthy subjects. The results indicated that none of the selected SNPs, which are frequently detected in the Caucasian population and linked with the transformation pathway of sex hormones, showed a significant association with FAGA. The study concluded that further research into the genetic background of androgenetic alopecia is necessary, considering ethnic differences and the size of the studied population as potentially significant factors.

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