Treatments for Alopecia Areata: A Network Meta-Analysis

    October 2023 in “ The Cochrane library
    Miriam Mateos-Haro, Monica Novoa-Candia, Guillermo Sánchez‐Vanegas, Andrea Correa-Pérez, Andrea Gaetano-Gil, Silvia Fernández-García, ­Daniel ­Ortega‐Quijano, Mayra Gizeth Urueña Rodriguez, David Saceda‐Corralo, Tayeb Bennouna-Dalero, Lucía Giraldo, Jaqueline Tomlinson, Sergio Vañó‐Galván, Javier Zamora
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    TLDR The medicine baricitinib was found to notably improve hair regrowth in alopecia areata, but more research is needed on its side effects and other treatments.
    This network meta-analysis reviewed 63 studies involving 4817 participants to evaluate various treatments for alopecia areata. The most significant finding was that the oral immunosuppressant baricitinib significantly increased short- and long-term hair regrowth compared to a placebo, backed by high-certainty evidence from two trials involving 1200 participants. However, the risk of serious side effects with baricitinib was inconclusive. The evidence for other treatments was generally of very low to low certainty, often due to a small number of studies with few participants. The review concluded that more high-quality studies are needed to evaluate the potentially useful therapies.
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