Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy

    July 2024 in “ International Journal of Molecular Sciences ”
    Su-Eon Jin, Jong‐Hyuk Sung
    Studysummary In this review, researchers introduced clinically tunable siRNA delivery systems for hair loss treatment, discussing design principles and analyzing relevant clinical trials to propose a framework for optimizing siRNA delivery in a clinical context.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 75

    1. Novel Anti-Dandruff Shampoo Incorporated With Ketoconazole-Coated Zinc Oxide Nanoparticles Using Green Tea Extract Journal of cosmetic dermatology · 2023
    2. Nanotechnology-Based Techniques for Hair Follicle Regeneration Biomaterials · 2023
    3. Hair Loss Treatments Take Aim at the Immune System Nature Biotechnology · 2023
    4. Approach to the Patient With Hair Loss Journal of the American Academy of Dermatology · 2023
    5. Dissolving Microneedles for Alopecia Treatment Colloids and surfaces. B, Biointerfaces · 2023
    6. An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing the Big Eight Strikes Cosmetics · 2023
    7. Unlocking the Potential of Cosmetic Dermal Delivery With Ethosomes: A Comprehensive Review Journal of Cosmetic Dermatology · 2023
    8. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    9. Advances in Transdermal siRNAs Delivery: A Review of Current Research Progress Non-coding RNA Research · 2023
    10. MicroRNA-205 Promotes Hair Regeneration by Modulating Mechanical Properties of Hair Follicle Stem Cells Proceedings of the National Academy of Sciences · 2023
    11. Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms Precision clinical medicine · 2023
    12. Androgenetic Alopecia: Therapy Update Drugs · 2023
    13. Nanotechnology-Based Strategies for Hair Follicle Regeneration in Androgenetic Alopecia 2023
    14. Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
    15. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    16. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    17. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2 Cells · 2023
    18. Trace Element Zinc and Skin Disorders Frontiers in Medicine · 2023
    19. Advances in Microneedles Research Based on Promoting Hair Regrowth Journal of Controlled Release · 2022
    20. Exosomes Based Advancements for Application in Medical Aesthetics Frontiers in Bioengineering and Biotechnology · 2022
    21. A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch Bioactive Materials · 2022
    22. Application of Niosomes in Cosmetics: A Systematic Review Cosmetics · 2022
    23. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    24. Effective And Economical Cell Therapy For Hair Regeneration Biomedicine & Pharmacotherapy · 2022
    25. A Lipid–Polymer Hybrid Nanoparticle-Loaded Dissolving Microneedle Patch for Promoting Hair Regrowth by Transdermal miR-218 Delivery Biomaterials Science · 2022
    26. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    27. Cucurbitacin Promotes Hair Growth in Mice by Inhibiting the Expression of Fibroblast Growth Factor 18 Annals of Translational Medicine · 2022
    28. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects Pharmaceuticals · 2022
    29. Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways British Journal of Dermatology · 2022
    30. Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles Pharmaceutics · 2022
    31. CXCL12 Inhibits Hair Growth Through CXCR4 Biomedicine & Pharmacotherapy · 2022
    32. A Systematic Review on the Lipid Composition of Human Hair International Journal of Dermatology · 2022
    33. Nanomaterials in Hair Care and Treatment Acta Biomaterialia · 2022
    34. Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022
    35. Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia Scientific Reports · 2022
    36. Advances in Hair Growth Faculty reviews · 2022
    37. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review Dermatology and therapy · 2021
    38. Safety and Efficacy of ALRV5XR in Men with Androgenetic Alopecia: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial EClinicalMedicine · 2021
    39. Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle Journal of Autoimmunity · 2021
    40. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    41. Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice Frontiers in Pharmacology · 2021
    42. The New Regenerative and Innovative Strategies in Hair Loss 2021
    43. Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial EClinicalMedicine · 2021
    44. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021
    45. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    46. Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia International Journal of Molecular Sciences · 2020
    47. RNA Sequence Analysis of Dermal Papilla Cells’ Regeneration in 3D Culture Journal of Cellular and Molecular Medicine · 2020
    48. An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects Cosmetics · 2020
    49. Development of Ethosome Comprising Combined Herbal Extracts and Its Effect on Hair Growth Advances in Traditional Medicine · 2020
    50. Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of Conservative Therapy Effectiveness Diagnostics · 2020
    51. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    52. Genetic Susceptibility to Alopecia The New England Journal of Medicine · 2019
    53. CXXC5: A Novel Regulator and Coordinator of TGF-β, BMP, and Wnt Signaling Journal of Cellular and Molecular Medicine · 2018
    54. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
    55. Nanotechnology Advances for Hair Loss Therapeutic Delivery · 2018
    56. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    57. Scalp Condition Impacts Hair Growth And Retention Via Oxidative Stress International journal of trichology · 2018
    58. Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata Journal of the American Academy of Dermatology · 2017
    59. Follicular Unit Extraction for Hair Transplantation: An Update Actas Dermo-Sifiliográficas · 2017
    60. Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process Clinical, Cosmetic and Investigational Dermatology · 2017
    61. A 6-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of a Marine Complex Supplement to Promote Hair Growth in Men with Thinning Hair Journal of Cosmetic Dermatology · 2016
    62. Applications and Limitations of Lipid Nanoparticles in Dermal and Transdermal Drug Delivery via the Follicular Route European journal of pharmaceutics and biopharmaceutics · 2015
    63. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    64. Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies International Journal of Nanomedicine · 2014
    65. The Human Hair: From Anatomy to Physiology International Journal of Dermatology · 2013
    66. Primary Cicatricial Alopecia: Diagnosis and Treatment Canadian Medical Association Journal · 2013
    67. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    68. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010
    69. Loose Anagen Hair Syndrome International Journal of Trichology · 2010
    70. Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery AAPS PharmSciTech · 2009
    71. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    72. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008
    73. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    74. A Comparison of Hair Quality and Cosmetic Acceptance Following the Use of Two Anti-Dandruff Shampoos Journal of Investigative Dermatology Symposium Proceedings · 2005
    75. The Biology of Hair Follicles The New England Journal of Medicine · 1999