Novel Anti-Dandruff Shampoo Incorporated With Ketoconazole-Coated Zinc Oxide Nanoparticles Using Green Tea Extract

    November 2023 in “ Journal of cosmetic dermatology ”
    Prerana V. Poojary, Souvick Sarkar, Adithi Ananda Poojary, Pooja Mallya, Raja Selvaraj, Ananthamurthy Koteshwara, Jesil Mathew Aranjani, Shaila Lewis
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    TLDR The new anti-dandruff shampoo with ketoconazole-coated zinc oxide nanoparticles is more effective against dandruff.
    The study developed a novel anti-dandruff shampoo incorporating ketoconazole (KTZ)-coated zinc oxide (ZnO) nanoparticles synthesized using green tea extract (GTE). This formulation demonstrated enhanced antifungal activity against Malassezia furfur, improved solubility, and better skin penetration of KTZ, while reducing its concentration to 1%. Characterization confirmed the formation of nanoparticles, and the shampoo showed ideal physical properties, including a pH of 6.9, stable foam production, and no dirt dispersion. The study concluded that this novel shampoo could be an effective alternative to existing anti-dandruff treatments, with no significant cytotoxicity observed.
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      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

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      A 23-year-old male is using 0.5 mg dutasteride daily, 5% minoxidil twice daily, and ketoconazole with zinc pyrithione shampoo twice a week to address diffused thinning and hair loss. He is seeking advice on whether his hair will regrow and if additional treatments are needed.

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