Advances in Transdermal siRNAs Delivery: A Review of Current Research Progress

    May 2023 in “ Non-coding RNA Research ”
    Albert Sufianov, Aferin Beilerli, Valentin Kudriashov, Tatiana Ilyasova, Bu Wenjie, Ozal Beylerli
    TLDR New delivery systems are improving siRNA treatments for skin conditions.
    This review discusses the challenges and recent advancements in the transdermal delivery of small interfering RNAs (siRNAs) for treating skin conditions. The main obstacle is the low skin permeability of siRNAs due to their negative charge, high polarity, and susceptibility to degradation. Recent progress has been made in developing delivery systems using lipids, polymers, cell-penetrating peptides, nanoparticles, and other agents to improve the efficiency of siRNA delivery. These innovations in drug delivery systems are crucial for enhancing the therapeutic potential of siRNAs in both cosmeceutical and pharmaceutical applications.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 14 results

      community Since there is so much hype for cosmeRNA and HMI-115...

      in Chat  47 upvotes 2 years ago
      Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

      community Concerns about CosmeRNA safety mechanisms

      in Treatment  3 upvotes 2 years ago
      Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

      community Anyone excited for CosmeRNA coming this month?

      in Product  171 upvotes 3 years ago
      CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

      community cosmeRNA finally now it's pyrilutamide turn

      in Chat  49 upvotes 2 years ago
      Hair loss treatments discussed include cosmeRNA, minoxidil, finasteride, RU58841, and pyrilutamide. Users debate effectiveness, side effects, and upcoming treatments, with some expressing skepticism and others optimism.

    Similar Research

    5 / 902 results