Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of Conservative Therapy Effectiveness

May 2020 in “ Diagnostics ”

Irina N Kondrakhina, Dmitry A. Verbenko, A M Zatevalov, Eugenia R. Gatiatulina, Alexandr A. Nikonorov, Dmitry Deryabin, Alexey A. Kubanov

plasma zinc levels androgenetic alopecia conservative therapy serum zinc level vitamin E level AGA zinc

Studysummary This study involving male patients with androgenic alopecia found that a higher baseline zinc plasma level, specifically above 10 µmol/L, may predict the success of treatment with 5% topical minoxidil, correlating with increased hair density and diameter in the parietal area.

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research The Role of Vitamins and Minerals in Hair Loss: A Review

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research The Diagnosis and Treatment of Hair and Scalp Diseases

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research Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

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research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

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research BMI and Levels of Zinc, Copper in Hair, Serum, and Urine of Turkish Male Patients with Androgenetic Alopecia

37 citations , March 2014 in “Journal of Trace Elements in Medicine and Biology”

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research Analysis of Serum Zinc and Copper Concentrations in Hair Loss

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research Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers

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research Nutrition and Hair Health: The Impact of Nutritional Deficiencies

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The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level

research The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level

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research Effect of Dietary Supplementation with INVERSION Femme on Slimming, Hair Loss, and Skin and Nail Parameters in Women

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research Diffuse Alopecia in a Child Due to Dietary Zinc Deficiency

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