Loose Anagen Hair Syndrome

Loose Anagen Syndrome (LAS) is a condition where anagen hairs, which are in the growth phase, can be easily and painlessly pulled out, often affecting children, especially young girls. The syndrome is characterized by anagen hairs that lack their sheath and show a 'floppy sock appearance' on trichogram, with histopathological findings indicating clefting between hair layers. While the exact cause is unclear, it is thought to involve premature keratinization of the inner root sheath. Diagnosis is based on the presence of more than 50% loose anagen hairs on a trichogram, and although LAS typically resolves on its own, minoxidil may be used in severe cases. The document highlights the importance of recognizing LAS, differentiating it from other hair disorders, and using appropriate diagnostic methods, particularly in children under six years old, to manage the condition effectively.