Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways

PRP injections promote hair growth and increase hair density in androgenic alopecia.

Hair follicle regeneration possible, more research needed.

Adding platelet-rich plasma improves hair density and thickness in androgenetic alopecia.

PRP treatment improves hair density and thickness for alopecia, but needs more research.

PRP injections improve hair density and thickness in women with hair loss.

PRP therapy and minoxidil combo works best for male hair loss.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

Both Platelet-Rich Plasma and Minoxidil foam increase hair count in women with hair loss, but Minoxidil is more effective. However, women were more satisfied with Platelet-Rich Plasma treatment.

SVF-PRP therapy effectively reverses hair loss effects.

QR678 treatments were more effective and comfortable for male hair loss than PRP treatments.

PRP growth factor concentrations vary, no significant hair growth difference found.

Jagged1 and Epidermal Growth Factor together significantly increased hair growth in mice with androgen-suppressed hair.

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

Platelet-Rich Plasma (PRP) is helpful for skin and hair treatments and works better when combined with other procedures.

PRP therapy safely improves hair growth in people with hair loss.

PRP injections improve hair thickness and density in hair loss, but more research needed.

Platelet-rich plasma treatment can significantly increase hair count and density in men with pattern baldness, and these improvements can last up to 3 months.

DKK-1 gene linked to hair loss in AGA and AA patients; more research needed for potential therapy.

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

PRP injections effectively treat hair loss, with positive results in both monthly and every three months treatments.

PRP treatment helps hair growth in most cases, but more research needed.

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.

Wnt1a-conditioned medium from stem cells helps activate cells important for hair growth and can promote hair regrowth.

VEGF gel increases hair growth but may have potential toxicity.

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

Wnt ligands are crucial for hair growth and repair.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively increases hair growth in men with AGA, works better for those over 30, and may cause some side effects.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

Androgens slow hair growth by altering Wnt signaling in balding cells.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

Testosterone increases hair follicle cell growth when beard or axillary skin cells are present together.

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Human keratinocytes do not naturally respond to androgens.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

EGFR is essential for normal hair development and follicle differentiation.

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

Testosterone helps beard and axillary hair cells grow by releasing growth factors from dermal papilla cells.

Young men with male pattern baldness lose hair density over time without treatment.