Research Progress in the Treatment of Non-Scarring Alopecia: Mechanism and Treatment

    May 2025 in “ Frontiers in Pharmacology
    Ruixian Guo, Yong-Kang Zhao, Ke-Jian Hu, K. Jia, Shi Wei, Yan Yi, Haiying Gong, Jia-Bo Wang, Yuan Gao
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    TLDR New treatments are needed for non-scarring alopecia due to current limitations.
    The document reviews the mechanisms and treatments for non-scarring alopecia, focusing on conditions like androgenetic alopecia, alopecia areata, and trichotillomania. It highlights FDA-approved treatments such as minoxidil, finasteride, ritlecitinib, and baricitinib, noting their varying effectiveness and side effects. The paper emphasizes the need for new treatments due to the multifactorial nature of alopecia and the limitations of existing therapies. It underscores the importance of understanding the complex interplay of factors contributing to non-cicatricial alopecia to improve therapeutic interventions. The document also discusses the potential of personalized treatment approaches and the integration of traditional and modern methods, highlighting the necessity for more real-world data and longitudinal studies to evaluate the safety and efficacy of these emerging treatments.
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      in Female  450 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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      in Research  830 upvotes 9 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community My scalp punch biopsy results🤔?

      in Female  7 upvotes 2 years ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

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      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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