Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies

May 2025 in “ Cells ”

Apoorva Mehta, Mateen Motavaf, Danyal Raza, Alison J. McLure, Kofi D. Osei-Opare, Lindsey A. Bordone, Alejandro A. Gru

hair follicle neogenesis Wnt/β-catenin signaling androgenetic alopecia scarring alopecia PTD-DBM finasteride minoxidil JAK-STAT inhibitors prostaglandin signaling stem cell-based therapies CRISPR gene editing Propecia Rogaine

TLDR New hair regrowth therapies show promise but need more research.

Recent advancements in hair regrowth therapies focus on hair follicle neogenesis and the Wnt/β-catenin signaling pathway, offering potential treatments for androgenetic and scarring alopecias. These therapies, including PTD-DBM, aim to surpass current treatments like finasteride and minoxidil by activating the Wnt/β-catenin pathway. The review also highlights the role of JAK-STAT inhibitors, prostaglandin signaling, and novel approaches like stem cell-based therapies and CRISPR gene editing. Challenges include replicating the hair follicle microenvironment, differences between animal models and humans, and immune rejection. Despite these hurdles, the document underscores the promise of these innovative strategies in addressing alopecia, emphasizing the need for further research to confirm efficacy and understand risks.

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