Dermal β-Catenin Is Required for Hedgehog-Driven Hair Follicle Neogenesis

May 2024 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Churlzu Lim, Annette Kaminaka, Soung-Hoon Lee, Simone Moore, Bruce N. Cronstein, Piul S. Rabbani, Mayumi Ito

β-catenin Wnt signaling Hedgehog signaling hair follicle neogenesis dermal papilla myofibroblasts transcriptome analysis wound fibroblasts beta-catenin Wnt pathway Hh pathway HFN DP cells

TLDR β-Catenin is essential for new hair growth after skin injury.

The study investigates the role of dermal Wnt/β-catenin signaling in hair follicle neogenesis (HFN) following large skin excisions in mice. It was found that Wnt/β-catenin signaling is essential for HFN, as its deletion in wound myofibroblasts prevents this process. Additionally, β-catenin is necessary for Hedgehog (Hh)-driven dermal papilla (DP) formation. Transcriptome analysis confirmed the activation of both Wnt/β-catenin and Hh pathways in DP cells. The findings suggest that future strategies to promote HFN should ensure the activation of both pathways in skin wound fibroblasts.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration During Wound Healing

5 citations, December 2021 in “Journal of Investigative Dermatology”

Hedgehog signaling in certain cells is crucial for hair growth during wound healing.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing

128 citations, August 2020 in “Cell stem cell”

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

145 citations, November 2018 in “Nature Communications”

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

research Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis

46 citations, March 2015 in “Regeneration”

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

research Wound Healing and Skin Regeneration

359 citations, January 2015 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations, June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations, July 2012 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations, June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations, March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations, March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

Related Community Posts Join

6 / 57 results

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Does melatonin dissolve in isopropyl alcohol

in Technology 7 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community Improvements, features, announcements

in General 169 upvotes 6 months ago

The conversation discusses improvements to a platform and mentions hair loss treatments including Minoxidil, finasteride, RU58841, and melatonin. It also highlights the addition of features like Google login, reply by email, keyword extraction, and a term glossary for better understanding of hair-related terminologies.

community Selling KY19382 powder a novel activator of Wnt/β-catenin signaling Product

in Product 3 upvotes 2 years ago

Selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. KY19382 is a growth agonist.

community Selling KY19382 powder a novel activator of Wnt/β-catenin signaling

in Product 2 years ago

The conversation is about selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. The seller offers worldwide shipping.

community Hair theory Scar tissue and Verteporfin

in Chat 26 upvotes 6 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

Related Research

8 / 8 results

research Engineered Skin Substitute Regenerates Skin with Hair Follicle Formation

5 citations, April 2021 in “Biomedicines”

The engineered skin substitute helped grow skin with hair on mice.

research KY19382, A Novel Activator of Wnt/β-Catenin Signaling, Promotes Hair Regrowth and Hair Follicle Neogenesis

June 2020

KY19382 helps to regrow hair and create new hair follicles.

research Activin A-Induced Signaling Controls Hair Follicle Neogenesis

5 citations, October 2016 in “Experimental Dermatology”

Activin A is important for creating new hair follicles.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites

51 citations, August 2013 in “Journal of Investigative Dermatology”

Human skin cells can create new hair follicles when transplanted into mice.

research Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin

24 citations, April 2012 in “Developmental Biology”

Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations, August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

61 citations, October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.