Dermal β-Catenin Is Required for Hedgehog-Driven Hair Follicle Neogenesis

May 2024 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Churlzu Lim, Annette Kaminaka, Soung-Hoon Lee, Simone Moore, Bruce N. Cronstein, Piul S. Rabbani, Mayumi Ito

β-catenin Wnt signaling Hedgehog signaling hair follicle neogenesis dermal papilla myofibroblasts transcriptome analysis wound fibroblasts beta-catenin Wnt pathway Hh pathway HFN DP cells

TLDR β-Catenin is essential for new hair growth after skin injury.

The study investigates the role of dermal Wnt/β-catenin signaling in hair follicle neogenesis (HFN) following large skin excisions in mice. It was found that Wnt/β-catenin signaling is essential for HFN, as its deletion in wound myofibroblasts prevents this process. Additionally, β-catenin is necessary for Hedgehog (Hh)-driven dermal papilla (DP) formation. Transcriptome analysis confirmed the activation of both Wnt/β-catenin and Hh pathways in DP cells. The findings suggest that future strategies to promote HFN should ensure the activation of both pathways in skin wound fibroblasts.

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