Dermal β-Catenin Is Required for Hedgehog-Driven Hair Follicle Neogenesis

    May 2024 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Churlzu Lim, Annette Kaminaka, Soung-Hoon Lee, Simone Moore, Bruce N. Cronstein, Piul S. Rabbani, Mayumi Ito
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    TLDR β-Catenin is essential for new hair growth after skin injury.
    The study investigates the role of dermal Wnt/β-catenin signaling in hair follicle neogenesis (HFN) following large skin excisions in mice. It was found that Wnt/β-catenin signaling is essential for HFN, as its deletion in wound myofibroblasts prevents this process. Additionally, β-catenin is necessary for Hedgehog (Hh)-driven dermal papilla (DP) formation. Transcriptome analysis confirmed the activation of both Wnt/β-catenin and Hh pathways in DP cells. The findings suggest that future strategies to promote HFN should ensure the activation of both pathways in skin wound fibroblasts.
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