Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies

    August 2024 in “ Current Protocols ”
    John P. Sundberg, Eddy H.C. Wang, Kevin J. McElwee
    Studysummary In this study, researchers described protocols using C3H/HeJ mice to reliably induce alopecia areata through full-thickness skin grafts or adoptive transfer of cultured lymphoid cells, offering valuable models for studying the disease and testing new drug therapies.
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    Research cited in this study 21

    1. CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata International Journal of Molecular Sciences · 2024
    2. Phenotyping Mice With Skin, Hair, Or Nail Abnormalities: A Systematic Approach And Methodologies From Simple To Complex Veterinary Pathology · 2023
    3. Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice Frontiers in immunology · 2022
    4. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    5. Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
    6. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    7. A Hair-Raising History of Alopecia Areata Experimental Dermatology · 2020
    8. 2-Deoxy D-Glucose Treatment Does Not Elicit a Hair Growth Response in Alopecia Areata Experimental Dermatology · 2019
    9. JAK Inhibitors for Treatment of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    10. Alopecia Areata in a Dog: Clinical, Dermoscopic, and Histological Features Skin appendage disorders · 2017
    11. Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment Experimental dermatology · 2015
    12. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    13. Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum Australasian Journal of Dermatology · 2013
    14. Equine Alopecia Areata: A Retrospective Clinical Descriptive Study at the University of California, Davis (1980–2011) Veterinary dermatology · 2013
    15. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    16. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010
    17. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    18. An Update on Alopecia Areata Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics · 2009
    19. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    20. Alopecia in the United States: Outpatient Utilization and Common Prescribing Patterns Journal of the American Academy of Dermatology · 2007
    21. Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species Pathobiology · 1998

    Related research 1

    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019