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research Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies

August 2024 in “Current Protocols”

In this study, researchers described protocols using C3H/HeJ mice to reliably induce alopecia areata through full-thickness skin grafts or adoptive transfer of cultured lymphoid cells, offering valuable models for studying the disease and testing new drug therapies.

research Molecular Mechanisms Affecting Development of Animal Fibers and Some Studies on Goats

June 2023 in “Livestock studies”

This review highlights the significance of animal fibers, examining the molecular mechanisms influencing hair follicle development and their impact on fiber quality and quantity, with a focus on studies involving Angora and cashmere goats.

Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

research Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

1 citations , December 2022 in “Pharmaceuticals”

This study found that a sub-fraction of Noni fruit, FEA-3, showed hair growth-promoting effects in a rabbit model of androgenic alopecia, similar to Minoxidil.

research 049 Investigating the immunomodulatory mechanism of dithranol in alopecia areata through blood-based in vitro studies

November 2025 in “Journal of Investigative Dermatology”

Dithranol reduces inflammation in alopecia areata by lowering certain immune responses.

research Studies on the effect of Betula platyphylla extract on human dermal papilla cell proliferation and its mechanism of action

December 2022 in “Journal of applied biological chemistry”

In this study, Betula platyphylla extract, particularly fraction H3-2, promoted human derma papilla cell proliferation and increased expression of certain growth factors, suggesting potential benefits for hair loss prevention.

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community Possible mechanism for creatine to induce hair loss identified

12 upvotes 3 years ago

Creatine may affect hair loss by reducing PGE2 levels, which could influence hair growth. The discussion highlights the need for more research on this potential mechanism.

community With studies showing that 0.2mg Finasteride is almost as effective as 5mg at reducing DHT, why is every doctor prescribing 1mg?

252 upvotes 9 months ago

Finasteride is prescribed at 1mg because it is FDA-approved and proven effective, despite evidence that 0.2mg may similarly reduce DHT. The 1mg dose is more effective for hair growth, and lower doses are less available.

community Do studies say Finasteride shed is real?

in Finasteride/Dutasteride 12 upvotes 1 year ago

Finasteride may cause hair shedding as part of the regrowth process, but there are no controlled trials confirming this. The shedding idea is mostly based on anecdotal reports and comparisons to how minoxidil works.

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learn Latanoprost

glaucoma medication with hair follicle stimulant effects

How does latanoprost work to make eyelashes and possibly scalp hair grow? Studies report that latanoprost, a prostaglandin analog, lengthens the anagen (growth) phase of hair follicles, which is the mechanism given for the eyelash thickening seen in glaucoma patients; on the scalp the evidence is one 16-man pilot study and animal work, so the effect there is unproven.

learn HMI-115

much-hyped research compound targeting prolactin receptor in scalp

learn GT20029

research compound made to degrade androgen receptors in scalp

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Sulforaphane

compound from cruciferous vegetables has some mild effects on DHT

learn Valproic acid

What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.

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