Minoxidil: A Comprehensive Review

    June 2021 in “ Journal of Dermatological Treatment ”
    Anik Gupta, Mamunur Rashid Talukder, M. Venkataraman, Mary A Bamimore
    Studysummary This study reported that while topical minoxidil exhibits hair regrowth in androgenetic alopecia, oral minoxidil 5 mg/day was more effective than topical forms after six months, with low doses also potentially effective for women and other hair loss types.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on tandfonline.com →
    Discuss this study in the Community →

    Research cited in this study 83

    1. Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose 2021
    2. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    3. A Novel Topical Combination of Minoxidil and Spironolactone for Androgenetic Alopecia: Clinical, Histopathological, and Physicochemical Study Dermatologic Therapy · 2020
    4. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    5. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    6. Minoxidil Sulfotransferase Enzyme (SULT1A1) Genetic Variants Predict Response to Oral Minoxidil Treatment for Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2020
    7. Efficacy and Safety of Very-Low-Dose Oral Minoxidil 1.25 mg in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2020
    8. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Cells · 2020
    9. Treatment of Male and Female Pattern Hair Loss with Sublingual Minoxidil: A Retrospective Case-Series of 64 Patients Journal of The European Academy of Dermatology and Venereology · 2020
    10. At The Crossroads Of Two Alopecias: Androgenetic Alopecia Pattern Of Hair Regrowth In Patients With Alopecia Areata Treated With Oral Janus Kinase Inhibitors JAAD case reports · 2020
    11. How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil? Journal of The American Academy of Dermatology · 2020
    12. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    13. Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia Cutaneous and Ocular Toxicology · 2019
    14. Very-Low-Dose Oral Minoxidil in Male Androgenetic Alopecia: A Study with Quantitative Trichoscopic Documentation Journal of The American Academy of Dermatology · 2019
    15. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    16. Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2019
    17. Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation Journal of Dermatological Treatment · 2019
    18. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    19. Effectiveness and Safety of Low-Dose Oral Minoxidil in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2019
    20. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    21. Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability and the Five C’s of Oral Therapy Dermatologic Therapy · 2018
    22. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    23. Low-Dose Daily Aspirin Reduces Topical Minoxidil Efficacy in Androgenetic Alopecia Patients Dermatologic Therapy · 2018
    24. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review Skin appendage disorders · 2018
    25. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    26. Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells International Journal of Trichology · 2018
    27. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    28. Extended Hair Transplant: Combination of Two Techniques Journal of Aesthetic & Reconstructive Surgery · 2017
    29. A Comparative Study of Microneedling with Platelet-Rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia International Journal of Trichology · 2017
    30. Management of Androgenetic Alopecia: A Comparative Clinical Study Between Plasma Rich in Growth Factors and Topical Minoxidil European Journal of Plastic Surgery · 2016
    31. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016
    32. Effect of Minoxidil Topical Foam on Frontotemporal and Vertex Androgenetic Alopecia in Men: A 104-Week Open-Label Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2015
    33. A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in Women with Self-Perceived Thinning Hair Dermatology Research and Practice · 2015
    34. A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men Skin Pharmacology and Physiology · 2015
    35. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    36. Scalp Micropigmentation: A Medical Tattoo Process for Hair Loss Facial Plastic Surgery Clinics of North America · 2013
    37. Cell-Based Treatments for Hair Loss: Research Update on Hair Cloning Hair transplant forum international · 2013
    38. Role of Platelet-Rich Plasma in the Management of Androgenetic Alopecia International Journal of Trichology · 2012
    39. A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 2011
    40. Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect Journal of Dermatological Science · 2011
    41. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    42. Hair Restoration Surgery in Asians Springer eBooks · 2010
    43. Randomized Clinical Trial Comparing 5% and 1% Topical Minoxidil for the Treatment of Androgenetic Alopecia in Japanese Men Journal of Dermatology · 2009
    44. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    45. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    46. A Review of Modern Surgical Hair Restoration Techniques Journal of Cutaneous and Aesthetic Surgery · 2008
    47. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    48. Bioengineering the Hair Follicle Organogenesis · 2007
    49. Follicular Cell Implantation: An Update on Hair Follicle Cloning Facial Plastic Surgery Clinics of North America · 2004
    50. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    51. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004
    52. Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia Archives of Dermatology · 2003
    53. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    54. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    55. Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp Journal of Dermatological Science · 1999
    56. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    57. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    58. Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia Dermatology · 1998
    59. Minoxidil Sulfation in the Hair Follicle Skin Pharmacology and Physiology · 1994
    60. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991
    61. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    62. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    63. Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1990
    64. Topical Minoxidil Used Before and After Hair Transplantation The Journal of dermatologic surgery and oncology · 1989
    65. The History of the Development of Minoxidil Clinics in Dermatology · 1988
    66. Treatment of Male Pattern Alopecia Using Topical Minoxidil in The Netherlands International Journal of Dermatology · 1988
    67. The German Double-Blind Placebo-Controlled Evaluation of Topical Minoxidil Solution in the Treatment of Early Male Pattern Baldness International Journal of Dermatology · 1988
    68. Topical Minoxidil in Androgenetic Alopecia: Scandinavian and Middle East Experience International Journal of Dermatology · 1988
    69. Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture Biochemical Pharmacology · 1988
    70. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    71. Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata Journal of The American Academy of Dermatology · 1987
    72. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987
    73. Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata Journal of The American Academy of Dermatology · 1987
    74. Use of Topical Minoxidil in the Treatment of Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    75. Dose-Response Study of Topical Minoxidil in Male Pattern Alopecia Journal of The American Academy of Dermatology · 1987
    76. Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica Drugs · 1987
    77. 2% Topical Minoxidil Solution in Male-Pattern Baldness: Preliminary European Results Dermatology · 1987
    78. Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster Archives of Dermatology · 1987
    79. Topical Tretinoin for Hair Growth Promotion Journal of the American Academy of Dermatology · 1986
    80. Dose-Response Study of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1986
    81. Topically Applied Minoxidil in Baldness International Journal of Dermatology · 1985
    82. Percutaneous Absorption of Minoxidil in Humans Archives of Dermatology · 1985
    83. Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use Drugs · 1981

    Related research 8

    1. Diseases of Hair 2022
    2. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    3. A Case of Contact Allergic Dermatitis to Topical Minoxidil Cureus · 2021
    4. Disorders of Hair DeckerMed Medicine · 2013
    5. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    6. Treatment of Androgenic Alopecia with Topical Minoxidil PubMed · 1991
    7. Chapter 20: Pathogenesis and Treatment of Alopecias Annual Reports in Medicinal Chemistry · 1989
    8. Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica Drugs · 1987