Treatment of Androgenic Alopecia with Topical Minoxidil

November 1991 in “ PubMed ”

Sarah Brenner, Ada Tamir

androgenic alopecia topical minoxidil vasodilator hypertrichosis hair density hair counts balding scalp Rogaine

TLDR Minoxidil, a topical solution, was found to slow balding in most cases and increase hair density in some, but only a few saw significant cosmetic improvement.

The document from 1991 discusses a study on the treatment of androgenic alopecia with topical minoxidil, a vasodilator initially marketed as an oral antihypertensive in 1979. The study followed 30 cases treated with a 2% topical solution of minoxidil, which was developed due to the occurrence of hypertrichosis as an adverse effect in most patients treated with the oral form. The treatment was found to be beneficial in 63% of the cases, slowing balding in most, and increasing hair density in a minority. However, only 6.6% of the cases achieved dramatic cosmetic improvement. The efficacy of the treatment was assessed through hair counts in a marked area on the balding scalp, as well as subjective evaluations by patients and physicians.

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