Whole Blood Transcriptome Profiling Identifies Candidate Genes Associated With Alopecia in Male Giant Pandas

April 2022 in “ BMC Genomics ”

Hsin-Hsin Shen, Caiwu Li, Ming He, Yan Huang, Jing Wang, Jing Luo, Minglei Wang, Bisong Yue, Xiuyue Zhang

alopecia differentially expressed genes DEGs Notch signaling pathway ribosome thermogenesis oxidative phosphorylation ferroptosis hair growth-related genes NOTCH1 SMAD3 TGFB1 hair loss Notch pathway hair growth genes

TLDR Researchers found genes linked to hair loss in male giant pandas.

The study investigated the genetic factors associated with alopecia in 11 male giant pandas, 4 of which had alopecia and 7 were healthy. The researchers identified 458 up-regulated and 211 down-regulated differentially expressed genes (DEGs) in the alopecia group. The up-regulated DEGs were significantly enriched in the Notch signaling pathway, while the down-regulated DEGs were enriched in the ribosome, thermogenesis, oxidative phosphorylation, and ferroptosis pathways. The study also identified 28 hair growth-related genes with altered expression, and three hub genes - NOTCH1, SMAD3, and TGFB1 - associated with alopecia. The findings suggest that alopecia in giant pandas may be due to abnormal expression of multiple genes and pathways, providing a foundation for further studies in prevention and treatment strategies.

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