Whole Blood Transcriptome Profiling Identifies Candidate Genes Associated With Alopecia in Male Giant Pandas

    April 2022 in “ BMC Genomics
    Hsin-Hsin Shen, Caiwu Li, Ming He, Yan Huang, Jing Wang, Jing Luo, Minglei Wang, Bisong Yue, Xiuyue Zhang
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    TLDR Researchers found genes linked to hair loss in male giant pandas.
    The study investigated the genetic factors associated with alopecia in 11 male giant pandas, 4 of which had alopecia and 7 were healthy. The researchers identified 458 up-regulated and 211 down-regulated differentially expressed genes (DEGs) in the alopecia group. The up-regulated DEGs were significantly enriched in the Notch signaling pathway, while the down-regulated DEGs were enriched in the ribosome, thermogenesis, oxidative phosphorylation, and ferroptosis pathways. The study also identified 28 hair growth-related genes with altered expression, and three hub genes - NOTCH1, SMAD3, and TGFB1 - associated with alopecia. The findings suggest that alopecia in giant pandas may be due to abnormal expression of multiple genes and pathways, providing a foundation for further studies in prevention and treatment strategies.
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