16 citations
,
March 2009 in “Skin Pharmacology and Physiology” This study found that the penetration enhancer SEPA™ significantly increased both the speed and amount of hair growth from minoxidil in balding stumptail macaques compared to Rogaine®.
112 citations
,
July 2008 in “Dermatologic Therapy” This review outlines the diagnosis and management of folliculitis decalvans, an inflammatory scalp disorder, and highlights Staphylococcus aureus and immune response deficiencies as key factors in its development.
10 citations
,
March 2008 in “Journal of Zoo and Wildlife Medicine” This case study describes successful treatment of a siamang's persistent Microsporum canis infection using a sustained-release clotrimazole varnish, leading to lesion resolution after two years of clinical signs.
28 citations
,
February 2008 in “PubMed” This study found that low iron stores are a risk factor for excessive hair loss in non-menopausal women.
39 citations
,
July 2007 in “SKINmed Dermatology for the Clinician” In this case study, a 4-year-old girl's hair loss stopped after six months of zinc supplementation and dietary changes, suggesting a possible link to low zinc levels.
103 citations
,
June 2007 in “Endocrinology and Metabolism Clinics of North America” This article discusses treatment options for androgenetic alopecia, noting that medical interventions like finasteride and minoxidil can halt and partially reverse hair loss in mild to moderate cases, especially when combined with surgery.
31 citations
,
April 2007 in “Experimental Dermatology” This study found that foot shock stress prolonged the telogen stage and delayed anagen induction in the hair cycle of non-depilated mice, potentially through stress-induced actions of substance P.
16 citations
,
April 2007 in “Journal of Medical Primatology” This study reports that a 14-year-old female rhesus monkey with alopecia universalis was found to have a T-cell-mediated autoimmune disease similar to human alopecia areata universalis.
98 citations
,
February 2007 in “Seminars in Cell & Developmental Biology” This review explores the hormonal regulation of hair growth and changes with season, age, and sexual development, and calls for improved treatments for hair disorders.
76 citations
,
December 2006 in “Journal of Dermatological Science” This study observed that Japanese women experience diffuse central hair loss after age 40, characterized by reduced hair density and thicker hair ratio rather than vellus-like hairs.
53 citations
,
November 2006 in “Journal of Endocrinology” This study found that prolactin plays a direct role in regulating the timing of hair growth cycles in mice by affecting the skin, rather than through other endocrine factors.
375 citations
,
July 2006 in “Journal of Investigative Dermatology” This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
34 citations
,
July 2006 in “Clinics in dermatology” This article reviews dermatological manifestations of endocrine diseases in dogs, such as hypothyroidism and hyperadrenocorticism, but reports no new clinical findings.
81 citations
,
January 2006 in “Journal of cellular physiology” This study found that the absence of the vitamin D receptor disrupts hair follicle structure during the first catagen in mice, linked to increased expression of the hairless gene.
21 citations
,
January 2006 in “Hormone Research in Paediatrics” In this case study, a girl with hereditary vitamin D resistant rickets had a novel mutation in the VDR gene that affected hair cycling without causing total alopecia, suggesting ligand-independent VDR function in hair cycling.
51 citations
,
November 2005 in “Journal of Medical Primatology” This study observed that hair loss in captive rhesus macaques varies with season, sex, and housing conditions, and is significantly correlated with HPA axis activity as indicated by faecal cortisol metabolites.
9 citations
,
April 2005 in “PubMed” This study found that diffuse alopecia in female squirrel monkeys is associated with chronic telogen effluvium and appears to be predominantly age-related, potentially serving as an animal model for human diffuse alopecia.
162 citations
,
August 2004 in “Journal of Investigative Dermatology” This study suggests that stress negatively affects hair growth by inducing inflammation and early hair cycle transitions in mice, which might inform strategies for managing stress-related hair loss in humans.
19 citations
,
July 2004 in “Journal of Medical Primatology” In this study, zinc toxicosis in infant baboons was attributed to excessive environmental exposure, highlighting the importance of cage design in captivity and potential use of baboons as a developmental model.
108 citations
,
July 2004 in “American Journal of Pathology” This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.
13 citations
,
July 2004 in “Skinmed” This article reviews the structure and function of hair follicles, diagnostic approaches, and treatments for nonscarring alopecias, but reports no new clinical results.
163 citations
,
November 2003 in “Journal of Investigative Dermatology” This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.
148 citations
,
September 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Alopecia areata is an autoimmune disorder causing hair loss, linked to specific hair follicle antigens and genetic factors.
32 citations
,
August 2003 in “Journal of the American Academy of Dermatology” This case report describes three adults with inflammatory tinea capitis mimicking bacterial infection, emphasizing the need to consider this diagnosis in similar cases; all were successfully treated with oral antifungal agents.
194 citations
,
March 2003 in “American Journal of Pathology” This study found that psychoemotional stress disrupts hair growth in mice by terminating anagen and suggests a potential pathway for pharmacological management of stress-related hair loss in humans.
239 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review explores the role of nutritional factors in hair loss, noting that iron and l-lysine supplementation may benefit some individuals, while excessive supplements can lead to hair shedding.
20 citations
,
January 2002 in “Laboratory Animals” This study identified a compound heterozygous mutation in a hairless rhesus macaque, which was associated with skin abnormalities similar to those in hairless mice and humans with APL.
115 citations
,
December 2001 in “Endocrinology” This study found that restoring vitamin D receptor expression specifically in the keratinocytes of VDR null mice prevented alopecia and enhanced hair follicle response during anagen initiation.
125 citations
,
September 2001 in “The FASEB Journal” This study demonstrated that stress inhibited hair growth in mice, likely through substance P-dependent activation of immune cells, highlighting a brain-hair follicle connection.
137 citations
,
April 2001 in “Journal of Clinical Investigation” This study found that alopecia in VDR-null mice persists despite undetectable vitamin D levels, indicating a defect in epithelial-mesenchymal communication due to the absence of ligand-independent receptor function.
12 citations
,
February 2001 in “Annals of Pharmacotherapy” This review found no specific treatment for postpartum alopecia was adequately studied to be recommended as effective, highlighting significant limitations in the available literature.
83 citations
,
January 2001 in “American journal of clinical dermatology” This review discusses the clinical features of trichotillomania and the challenges in its diagnosis and treatment, reporting no new clinical findings while highlighting the need for specialized therapy and better therapeutic options.
50 citations
,
March 2000 in “American Journal of Clinical Dermatology” This article discusses the etiology, clinical features, and treatment of alopecia areata but presents no new clinical findings, underlining the palliative nature of current therapies.
126 citations
,
October 1998 in “Experimental Dermatology” This review provides an overview of the hairless gene in mice and humans, discussing its structure, expression, and implications for understanding skin physiology and human disorders related to gene disruption, but it reports no new empirical findings.
20 citations
,
September 1998 in “PubMed” In this study, a dietary protein deficiency was identified as the cause of alopecia and weight loss in captive western lowland gorillas, and protein supplementation improved their condition.
127 citations
,
September 1996 in “British Journal of Dermatology” This study found that cutaneous signs such as chilblains and urticaria were notably common in British patients with systemic lupus erythematosus, while subacute cutaneous lesions were less frequent.
26 citations
,
August 1995 in “The journal of experimental zoology/Journal of experimental zoology” This study found that administering melatonin to ferrets can advance the timing of fur growth and reproductive cycles influenced by daylength and hormonal control.
75 citations
,
January 1995 in “American journal of primatology” In this study, seasonal hair loss was most pronounced in low-ranking male vervet monkeys, and changes in scrotal color and hyperpigmentation also correlated with hair loss, but underlying causes were not identified.
62 citations
,
December 1994 in “Journal of Endocrinology/Journal of endocrinology” In this study, administrating ovine prolactin accelerated secondary hair follicle reactivation and moulting in cashmere goats, while bromocriptine delayed these processes.
13 citations
,
April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
69 citations
,
March 1993 in “Archives of Dermatology” This article proposes five mechanisms for telogen effluvium based on changes in the follicular cycle, which are supported by clinical findings, highlighting the condition's diverse causes.
214 citations
,
March 1993 in “Archives of Dermatology” This article proposes five different mechanisms for telogen effluvium, supported by clinical findings, based on changes in different phases of the hair cycle.
12 citations
,
April 1990 in “PubMed” This review discusses physiologic skin changes and various dermatoses associated with pregnancy but reports no new clinical findings, highlighting limited understanding of some conditions' etiologies.
70 citations
,
March 1980 in “Journal of Nutrition” Zinc deficiency in monkeys causes skin issues and reproductive problems, but supplementation reverses these effects.
20 citations
,
August 1979 in “PubMed” This study found that adding zinc to the drinking water improved hair coat and skin condition in moustached marmosets with symptoms resembling zinc deficiency.
54 citations
,
September 1972 in “British journal of nutrition” Malnutrition severely harms growth and development in young baboons.
23 citations
,
October 1971 in “BMJ” This case report describes a woman who experienced diffuse hair loss both after stopping oral contraceptives and after childbirth, suggesting a similar pathogenesis in these situations.