Cells and Structures Involved in Hair Follicle Regeneration: An Introduction

January 2022 in “ Stem cell biology and regenerative medicine ”

Jerry Tsai, Luis A. Garza

hair follicle regeneration macrophages Lgr5+ stem cells AKT/β-catenin pathway noncoding dsRNA lymphatic vessels hair follicle stem cell niche vascular endothelial growth factor VEGF minoxidil cutaneous blood flow extracellular vesicles exosomes cutaneous remodeling induced pluripotent stem cells hair-bearing human skin Rogaine iPS cells

TLDR The document concludes that hair follicle regeneration involves various factors like stem cells, noncoding dsRNA, lymphatic vessels, growth factors, minoxidil, exosomes, and induced pluripotent stem cells.

The document discusses the various factors and mechanisms involved in hair follicle regeneration. It emphasizes the role of macrophages in activating Lgr5+ stem cells and hair follicle regeneration via the AKT/β-catenin pathway. It also mentions the role of noncoding dsRNA in promoting regeneration after skin wounding and the interaction of lymphatic vessels with the hair follicle stem cell niche during skin regeneration. The document further highlights the role of vascular endothelial growth factor (VEGF) in controlling hair growth and follicle size, and the role of minoxidil in stimulating cutaneous blood flow in human balding scalps. The role of extracellular vesicles, particularly exosomes, in cutaneous remodeling and hair follicle dynamics is also discussed. Lastly, the document discusses the potential of induced pluripotent stem cells in treating skin conditions and generating hair-bearing human skin.

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research Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

77 citations , August 2020 in “Cell”

Muscles and nerves that cause goosebumps also help control hair growth.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

22 citations , July 2020 in “Journal of The American Academy of Dermatology”

DSC cell injections significantly improved hair density and diameter, showing potential as a hair loss treatment.

research Immune Modulation of Hair Follicle Regeneration

29 citations , May 2020 in “npj Regenerative Medicine”

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

research Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding

28 citations , April 2020 in “Seminars in Cell & Developmental Biology”

Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.

research Immune Cell Regulation of the Hair Cycle

27 citations , February 2020 in “Experimental Dermatology”

Immune cells affect hair growth and could lead to new hair loss treatments.

research Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation

49 citations , September 2019 in “British Journal of Dermatology”

Wnt signaling is important for the change from the resting phase to the growth phase in human hair cycles.

research Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo

44 citations , September 2019 in “The EMBO Journal”

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , July 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics

38 citations , June 2019 in “International Journal of Molecular Sciences”

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

101 citations , April 2019 in “Cell Stem Cell”

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

research Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner

36 citations , October 2018 in “Journal of Investigative Dermatology”

Macrophages help hair growth after injury through CX3CR1 and TGF-β1.

research Olfactory Receptor OR2AT4 Regulates Human Hair Growth

82 citations , September 2018 in “Nature Communications”

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

research M2 Macrophages Promote Wound-Induced Hair Neogenesis

27 citations , September 2018 in “Journal of Dermatological Science”

M2 macrophages, a type of immune cell, help in new hair growth on scars by producing growth factors.

research JAK Inhibitors for Treatment of Alopecia Areata

63 citations , September 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

JAK inhibitors can effectively reverse hair loss in people with alopecia areata.

research External Light Activates Hair Follicle Stem Cells Through Eyes Via an ipRGC–SCN–Sympathetic Neural Pathway

61 citations , June 2018 in “Proceedings of the National Academy of Sciences of the United States of America”

Light can turn on hair growth cells through a nerve path starting in the eyes.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , June 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research Never Too Old to Regenerate? Wound-Induced Hair Follicle Neogenesis After Secondary Intention Healing in a Geriatric Patient

7 citations , May 2018 in “Journal of Tissue Viability”

An 80-year-old patient grew new hair on a wound, showing that elderly people can still regenerate hair.

research Emerging Nonmetabolic Functions of Skin Fat

65 citations , January 2018 in “Nature Reviews Endocrinology”

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

27 citations , October 2017 in “British Journal of Dermatology”

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

research After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration

27 citations , July 2017 in “Journal of Investigative Dermatology”

After skin is damaged, noncoding dsRNA helps prostaglandins and Wnts work together to repair tissue and promote hair growth.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations , March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis

106 citations , December 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

research Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations , January 2016 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , December 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Defining Dermal Adipose Tissue

218 citations , September 2014 in “Experimental Dermatology”

Skin fat cells help with skin balance, hair growth, and healing wounds.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations , July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.

research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

256 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Growing human skin cells in a 3D environment can stimulate new hair growth.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , July 2012 in “Nature”

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Induction of De Novo Hair Regeneration in Scars After Fractionated Carbon Dioxide Laser Therapy in Three Patients

20 citations , September 2011 in “Dermatologic Surgery”

Laser therapy helped new hair grow in scarred skin for three patients.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations , February 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations , November 2010 in “The American Journal of Pathology”

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

research Alopecia Areata Update

244 citations , February 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations , December 2007 in “American Journal of Pathology”

Stress-related substance P may lead to hair loss and negatively affect hair growth.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

research Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model

107 citations , September 2002 in “Journal of Investigative Dermatology”

Researchers found that hair shedding happens mostly when new hair is growing and involves a unique process.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

research Neural Mechanisms of Hair Growth Control

101 citations , January 1997 in “Journal of Investigative Dermatology Symposium Proceedings”

Nerves and chemicals in the body can affect hair growth and loss.

research Alterations in scalp blood flow after the epicutaneous application of 3% minoxidil and 0.1% hexyl nicotinate in alopecia

25 citations , November 1987 in “British Journal of Dermatology”

Minoxidil didn't increase scalp blood flow for hair growth, but hexyl nicotinate did.

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

research Hypertrichosis due to minoxidil

45 citations , November 1979 in “British Journal of Dermatology”

Minoxidil causes excessive hair growth in almost all patients.

research The Formation of Vellus Hair Follicles from Human Adult Epidermis1

73 citations , July 1956 in “Journal of Investigative Dermatology”

Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.

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research Pre-Aggregation of Scalp Progenitor Dermal and Epidermal Stem Cells Activates the WNT Pathway and Promotes Hair Follicle Formation In Vitro and In Vivo Systems

17 citations , December 2019 in “Stem Cell Research & Therapy”

Grouping certain skin cells together activates a growth pathway that helps create new hair follicles.

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations , April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

Estrogen affects hair growth and skin cell multiplication.